辅酶Q10和维生素E与黄精赞育胶囊联合治疗弱精症的临床效果观察  

Clinical observation of coenzyme Q10 and vitamin E combined with huangjingzanyu capsule in the treatment of asospermia

作　　者：刘利敏[1] 凌晓辉[1] 柯洁荣 何妙玲 林淑如 LIU Limin;LING Xiaohui;KE Jierong;HE Miaoling;LIN Shuru(Huizhou Central People's Hospital,Huizhou 516000,China)

机构地区：[1]惠州市中心人民医院,广东惠州516000

出　　处：《临床医药实践》2024年第4期248-251,共4页Proceeding of Clinical Medicine

基　　金：广东省中医药局科技项目(项目编号:20221403)。

摘　　要：目的:观察辅酶Q10和维生素E与黄精赞育胶囊联合治疗弱精症的临床疗效。方法:选择2022年1月-2022年9月初次就诊并接受治疗的弱精症患者(确诊为肾虚精亏夹湿热型)90例,采用随机对照法分为对照1组(A组)、对照组2组(B组)和观察组(C组)。A组给予辅酶Q10和维生素E治疗,B组给予黄精赞育胶囊治疗,C组给予黄精赞育胶囊+辅酶Q10和维生素E治疗。治疗结束6个月后随访配偶妊娠情况。比较三组患者的精液质量[精子浓度、精子活力(PR%)、正常形态率、DNA碎片率(DFI)和精液活性氧(ROS)含量]及患者配偶的临床妊娠率、显效率、有效率。结果:三组间治疗前、治疗后的精液质量各项比较,差异均无统计学意义(P>0.05)。A组治疗后的精子活力和正常形态率高于治疗前,差异有统计学意义(P<0.05);治疗后的精子浓度与治疗前比较,差异无统计学意义(P>0.05)。B组治疗后的精子浓度、精子活力、正常形态率与治疗前比较,差异均无统计学意义(P>0.05)。C组治疗后精子活力高于治疗前,差异有统计学意义(P<0.05);治疗后精子浓度和正常形态百分率与治疗前比较,差异无统计学意义(P>0.05)。治疗后三组患者的精子DNA碎片率、精浆ROS生成量均低于治疗前,差异有统计学意义(P<0.05)。三组临床妊娠率、显效率和总有效率比较,差异无统计学意义(P>0.05)。结论:联合用药与辅酶Q10和维生素E治疗效果相似,均略优于黄精赞育胶囊治疗效果,联合用药是否优于辅酶Q10和维生素E需要扩大样本量进一步研究。Objective:To observe the clinical effect of coenzyme Q10 and vitamin E combined with Huangjingzanyu capsule in the treatment of asthenospermia.Methods:Patients with asthenospermia who first visited and received treatment in hospital from January 2022 to September 2022(diagnosed as kidney deficiency and essence deficiency with dampness-heat type)were taken as the research objects.A randomized controlled clinical study was conducted to randomly divide 90 enrolled patients into 3 groups,with 30 cases in each group.The course of treatment was 3 months.Control group 1(group A)was given coenzyme Q10 and vitamin E therapy,control group 2(group B)was given hungjingzanyu capsule,observation group(Group C)was given huangjingzanyu capsule and coenzyme Q10 and vitamin E.The pregnant status of the spouses was followed up 6 months after treatment.The sperm quality[sperm concentration,motility(PR%),normal morphology rate,DNA fragment rate(DFI)and reactive oxygen species(ROS)content in semen]and clinical pregnancy rate,markedly effective rate and effective rate of patients'spouses were compared among the three groups.Results:There was no significant difference in semen quality between the three groups before and after treatment(P>0.05).In Group A,the sperm motility and the percentage of normal morphology after treatment were significantly higher than those before treatment(P<0.05),but the sperm concentration after treatment was not significantly different from those before treatment(P>0.05).There were no significant differences in sperm concentration,sperm motility and normal morphology between before and after treatment in Group B(P>0.05).In Group C,the sperm motility after treatment was significantly higher than that before treatment(P<0.05),but the sperm concentration and the percentage of normal morphology after treatment were not significantly different from that before treatment(P>0.05).After treatment,the rate of sperm DNA fragments and the amount of ROS production in seminal plasma were significantly lower than those bef

关 键 词：黄精赞育胶囊 辅酶Q10和维生素E 精液质量 

分 类 号：R698.2[医药卫生—泌尿科学]