基于淋巴系统的药物及其递送系统研究进展  

Drugs that act in the lymphatic system and lymphatic drug delivery:review and perspective

作　　者：胡罗娟 顾景凯[2] 尤启冬[1,3] 韩思飞 HU Luo-juan;GU Jing-kai;YOU Qi-dong;HAN Si-fei(School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Research Center for Drug Metabolism,School of Life Sciences,Jilin University,Changchun 130012,China;Jiangsu Key Laboratory of Drug Design and Optimization,China Pharmaceutical University,Nanjing 210009,China;Faculty of Pharmacy and Pharmaceutical Sciences,Monash University,Melbourne VIC3052,Australia)

机构地区：[1]中国药科大学药学院,江苏南京210009 [2]吉林大学生命科学学院,药物代谢研究中心,吉林长春130012 [3]江苏省药物分子设计与成药性优化重点实验室(中国药科大学),江苏南京210009 [4]莫纳什大学药学院,澳大利亚墨尔本VIC3052

出　　处：《药学学报》2024年第3期565-573,共9页Acta Pharmaceutica Sinica

基　　金：2022年国家海外高层次青年人才计划;江苏省药物分子设计与成药性优化重点实验室资助项目(DDORC202202).

摘　　要：近年来,位于淋巴系统的生物学靶标越来越多地被发现和利用;以调控淋巴系统功能或纠正淋巴系统病理改变为主要作用机制的药物逐渐成为研发热点之一;药物经淋巴系统的吸收、转运、代谢与递送研究与相应递送系统的开发也正引起重视。很多研究成果正被尝试用于免疫治疗、炎症调控、新型疫苗等重要领域,为肿瘤、自身免疫病、感染类疾病、代谢综合征等多类别重大疾病的治疗带来新机会。本文简要介绍了淋巴系统的结构与生理功能,淋巴系统内药物靶标与相关药物研究,以及药物经淋巴系统转运的模式与递送技术,希望给药学科学工作者、产业界和监管科学界专业人士提供参考。The lymphatic system,as well as pathological changes of the lymphatic system,underlies the progress of an array of diseases and conditions,including cancer,inflammation and autoimmune disorders,infectious diseases and metabolic syndrome.A variety of biological targets in the lymphatic system can be employed to modulate these high-burden diseases,and the pharmacokinetics and drug delivery strategies in the context of lymphatics are of critical importance to optimise drug exposure to lymphatic-related targets.As such,research and drug development in this field has gained increasing attention in recent years.This article aims to provide an overview of pharmaceutical research with a focus on the lymphatic system and therapeutic targets within the lymphatics,followed by lymphatic drug delivery approaches,which may be of interest for researchers in academia,pharmaceutical industry and regulatory sciences.

关 键 词：淋巴系统 淋巴药物递送 免疫治疗 大分子药物代谢动力学 纳米药物 

分 类 号：R944[医药卫生—药剂学]