超声诊断或治疗用微/纳泡的研究进展  

Research progress in micro/nanobubbles for ultrasound diagnosis or treatment

作　　者：安青青 李晨曦 杨少坤[1] 何晓明[1] 王岳恒[2] 何朝星[1] 向柏[1] AN Qing-qing;LI Chen-xi;YANG Shao-kun;HE Xiao-ming;WANG Yue-heng;HE Chao-xing;XIANG Bai(School of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China;The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学药学院,河北石家庄050017 [2]河北医科大学第二医院,河北石家庄050000

出　　处：《药学学报》2024年第3期581-590,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81973251);河北省引进留学人员资助项目(C20230351);河北省2021年度医学科学研究课题(20211108).

摘　　要：过去几十年中,微泡作为超声造影剂广泛应用于肿瘤成像领域,随着研究的逐渐深入,超声靶向微泡破坏技术结合载药微泡能够实现药物的精准释放,发挥治疗作用。微泡作为微米级载体难以透过肿瘤内皮细胞间隙,纳米级递药系统——纳泡应运而生,两者结构特征相似,但尺寸上的差异突显出纳泡在药物递送方面独特的优势。本综述以外壳材料为分类原则,对用作超声诊断或治疗的微/纳泡进行归纳总结,并探讨其未来可能的发展方向,为微/纳泡的后续开发提供参考。In the past few decades,microbubbles were widely used as ultrasound contrast agents in the field of tumor imaging.With the development of research,ultrasound targeted microbubble destruction technology combined with drug-loaded microbubbles can achieve precise drug release and play a therapeutic role.As a micronscale carrier,microbubbles are difficult to penetrate the endothelial cell space of tumors,and nano-scale drug delivery system—nanobubbles came into being.The structure of the two is similar,but the difference in size highlights the unique advantages of nanobubbles in drug delivery.Based on the classification principle of shell materials,this review summarized micro/nanobubbles used for ultrasound diagnosis or treatment and discussed the possible development directions,providing references for the subsequent development.

关 键 词：超声造影剂 微泡 纳泡 超声靶向微泡破坏 诊断 治疗 

分 类 号：R943[医药卫生—药剂学]