陕北细叶远志中的一个新[口山]酮  

A new xanthone from the Polygala tenuifolia Willd.of northern Shaanxi

作　　者：贾云鹏 刘璐 杨晓军[1] 王超 任火冰 JIA Yun-peng;LIU Lu;YANG Xiao-jun;WANG Chao;REN Huo-bing(College of Chemistry and Chemical Engineering,Yan'an University,Yan′an 716000,China;Shaanxi Yuankang Traditional Chinese Medicine Industry Development Co.,Ltd.,Suide 718000,China)

机构地区：[1]延安大学化学与化工学院,陕西延安716000 [2]陕西援康中药产业发展有限公司,陕西绥德718000

出　　处：《药学学报》2024年第3期667-672,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(31860089);陕西省自然科学基金资助项目(2019JM-516);榆林市科学技术局资助项目(CXY-2020-069);延安大学大学生创新训练项目(2022090).

摘　　要：采用硅胶和凝胶柱色谱等分离技术,从陕北细叶远志(Polygala tenuifolia Willd.)干燥根皮的乙醇提取物中分离得到10个化合物。结合现代波谱学方法及其理化性质对其结构分析,确定其结构分别为β-谷甾醇(1)、细叶远志皂苷(2)、6-甲氧基香豆素(3)、7-苯基-1-羟基-2,3,6-三甲氧基[口山]酮(4)、1,8-二羟基-3,4,7-三甲氧基[口山]酮(5)、芒果苷(6)、槲皮素-3-O-β-D-葡萄糖苷(7)、芦丁(8)、丁香醛(9)、水杨酸(10)。其中化合物3、4和5为首次从远志属植物中分离得到,化合物4为一新[口山]酮。采用Ellman比色法对化合物3、4和5进行乙酰胆碱酯酶抑制活性测试,结果表明,化合物3和5对乙酰胆碱酯酶具有中等强度的抑制活性,化合物4的抑制作用较弱。Ten compounds were isolated and purified from ethanol extracts of dried roots bark of Polygala tenuifolia Willd.by various chromatography techniques such as silica gel and Sephadex LH-20.Their structures were identified by analysis of physicochemical properties and spectral data,and determined asβ-sitosterol(1),tenuifolin(2),6-methoxy coumarin(3),7-phenyl-1-hydroxy-2,3,6-trimethoxyxanthone(4),1,8-dihydroxy-3,4,7-trimethoxyanthone(5),mangiferin(6),quercetin-3-O-β-D-glucoside(7),rutin(8),syringaldehyde(9),salicylicacid(10).Among them,compounds 3,4 and 5 were isolated from the genus of Ploygala for the first time and compound 4 was a new xanthone.The acetylcholinesterase inhibitory activities of compounds 3,4 and 5 were evaluated by Ellman colorimetric method,compounds 3 and 5 exhibited moderate inhibitory activity,compound 4 exhibited weak inhibitory activity.

关 键 词：远志 化学成分 [口山]酮 乙酰胆碱酯酶抑制活性 

分 类 号：R284[医药卫生—中药学]