窝儿七中2个新的黄酮苷类化合物  

Two new flavonoid glycosides from Diphylleia sinensi

作　　者：王浩杰 赵晨 孙彦君[1,2,3] 弓建红 白红云[2,3] 陈辉 冯卫生 WANG Hao-jie;ZHAO Chen;SUN Yan-jun;GONG Jian-hong;BAI Hong-yun;CHEN Hui;FENG Wei-sheng(Henan University of Chinese Medicine,Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of China,Zhengzhou 450046,China;School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Engineering and Technology Center for Chinese Medicine Development of Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046 [2]河南中医药大学药学院,河南郑州450046 [3]河南省中药开发工程技术中心,河南郑州450046

出　　处：《药学学报》2024年第3期673-677,共5页Acta Pharmaceutica Sinica

基　　金：河南中医药大学省属高校基本科研业务专项(2014KYYWFQN26);河南中医药大学科技创新人才(2016XCXRC01);河南省科技攻关(192102310438);河南省中医药科学研究专项(20-21ZY1039)

摘　　要：采用硅胶、MCI、凝胶、ODS等柱色谱以及半制备液相等现代色谱分离技术对窝儿七(Diphylleia sinensi)乙醇提取物的乙酸乙酯洗脱部位和甲醇洗脱部位的化学成分进行分离纯化,得到5个黄酮苷类化合物。运用现代波谱学方法(1D NMR、2D NMR、UV、IR和MS)鉴定结构,分别为山荷叶酮苷A(1)、山荷叶酮苷B(2)、槲皮素-3-O-β-D-葡萄糖苷(3)、山柰酚-3-O-β-D-葡萄糖苷(4)、山柰酚-3-O-(6″-O-乙酰)-β-D-葡萄糖苷(5)。化合物1和2为2个新的黄酮苷类化合物,化合物3和5为首次从山荷叶属中分离得到。Five flavonoid glycosides were isolated from the methanol and ethyl acetate fractions of the ethanol extract of Diphylleia sinensi by using various chromatographic methods,including silica gel,MCI gel,Sephadex LH-20,ODS and semi-preparative HPLC.The structures of the isolated compounds were identified as diphyflavo-noid A(1),diphyflavonoid B(2),quercetin-3-O-β-D-glucopyranoside(3),kaempferol-3-O-β-D-glucopyranoside(4),kaempferol-3-O-(6″-O-acetyl)-β-D-glucopyranoside(5)by spectroscopy methods(1D NMR,2D NMR,UV,IR,and MS).Compounds 1 and 2 were two new flavonoid glycosides,and compounds 3 and 5 were isolated from the genus Diphylleia for the first time.

关 键 词：窝儿七 化学成分 黄酮苷类化合物 提取分离 山荷叶属 

分 类 号：R284[医药卫生—中药学]