高血压患者服用硝苯地平控释片后脉搏波传导时间的变化及影响因素  

Changes and influencing factors of pulse wave transit time in hypertensive patients after administration of nifedipine controlled-release tablets

作　　者：王利 单晨[2] 刘克春 WANG Li;SHAN Chen;LIU Kechun(Clinical Medical College of Xizang Minzu University,Xianyang 712082;Chinese PLA General Hospital Hainan Branch,Sanya 572013;Zhangqiu District People’s Hospital,Jinan 250200,China)

机构地区：[1]西藏民族大学临床医学院,陕西咸阳712082 [2]解放军总医院海南医院,海南三亚572013 [3]章丘区人民医院介入科,山东济南250200

出　　处：《西安交通大学学报（医学版）》2024年第2期258-261,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省教育厅科学研究项目(21JK0951)。

摘　　要：目的 研究硝苯地平控释片对高血压患者左腕脉搏波传导时间(PWTT)的影响。方法 选取2021年8月—2022年12月于解放军总医院海南医院住院收治的原发性高血压患者262例,根据是否服用硝苯地平控释片将其分为观察组(n=140)和对照组(n=122)。采用智能腕表收集患者服药后0.5 h、2.5 h、4.5 h、6.5 h、8.5 h的左腕PWTT进行统计学分析。结果 (1)观察组(93±15,93±13,87±15,85±15,84±10)与对照组(98±18,92±16,90±10,89±8,89±9)的PWTT随着时间的延长逐渐缩短(F=11.448,P<0.001)。(2)随着时间的延长,观察组与对照组PWTT下降的幅度相同(F=2.206,P>0.05)。(3)观察组和对照组5个时间点PWTT无统计学差异(F=1.164,P>0.05)。结论 硝苯地平控释片对原发性高血压患者左腕PWTT无影响。Objective To explore the effect of nifedipine controlled-release tablets on left wrist pulse wave transit time(PWTT) in hypertensive patients.Methods We selected 262 essential hypertensive patients hospitalized at Chinese PLA General Hospital Hainan Branch from August 2021 to December 2022.The patients were divided into observation group(n=140) and control group(n=122) according to whether or not taking nifedipine controlled release tables.The left wrist PWTT at 0.5 h,2.5 h,4.5 h,6.5 h and 8.5 h after administration of the medicine was collected with a smart watch for statistical analysis.Results(1)The PWTT in the observation group(93±15,93±13,87±15,85±15,84±10) and the control group(98±18,92±16,90±10,89±8,89±9) decreased gradually with the extension of time(F=11.448,P<0.001).(2)The PWTT decreased by the same amplitude(F=2.206,P>0.05).(3)There was no significant difference in PWTT between the observation group and the control group at five time points(F=1.164,P>0.05).Conclusion Administration of nifedipine controlled-release tablets does not affect PWTT of primary hypertensive patients' left wrist.

关 键 词：硝苯地平 高血压 脉搏波传导时间(PWTT) 

分 类 号：R543.5[医药卫生—心血管疾病]