1例伏立康唑与硝苯地平相互作用致急性肾损伤的药学实践  

Pharmaceutical Practice of Acute Renal Injury Induced by Interaction Between Voriconazole and Nifedipine:A Case Report

作　　者：张春燕[1] 任晓蕾[1] 张晓红[1] ZHANG Chunyan;REN Xiaolei;ZHANG Xiaohong(Department of Pharmacy,People's Hospital,Peking University,Beijing 100044,China)

机构地区：[1]北京大学人民医院药学部,北京100044

出　　处：《医药导报》2024年第4期636-638,共3页Herald of Medicine

摘　　要：目的探讨伏立康唑与硝苯地平相互作用致急性肾损伤的机制及处理。方法药师分析1例并用硝苯地平控释片和伏立康唑片导致急性肾损伤的原因,提出治疗建议,停用可疑药物头孢他啶及伏立康唑,根据分析结果决定后续治疗。结果医生采纳药师建议,患者急性肾损伤逐渐恢复。结论临床诊治过程中应关注药物相互作用,尤其是基于肝药酶CYP450的相互作用,从而提高疗效,同时减少不良反应。Objective To explore the mechanism and management of acute kidney injury induced by the interaction between voriconazole and nifedipine.Methods A patient with acute kidney injury was treated with nifedipine controlled-release tablets and voriconazole tablets at the same time.Pharmacists analyzed drug interactions and drug characteristics during diagnosis and treatment and proposed treatment recommendations,discontinued suspected drugs(cefotaxime and voriconazole),and determined subsequent treatment based on the analysis results.Results The doctor accepted the advice and the patient gradually recovered from acute kidney injury.Conclusion Drug-drug interactions,especially those based on the interaction of liver drug enzyme CYP450,should be paid attention to in clinical diagnosis and treatment,to improve efficacy and reduce adverse reactions.

关 键 词：伏立康唑 硝苯地平 相互作用 急性肾损伤 

分 类 号：R969[医药卫生—药理学]