补体C3水平对冻融胚胎移植妊娠结局的早期预测价值  

Role of complement C3 in early predicting pregnancy outcomes of frozen⁃thawed embryo transfer

作　　者：唐志霞[1] 马双影 张影 盛佳佳[1] 李娟[1] 何晶晶[1] 宣恒华[1] 洪名云[1] TANG Zhixia;MA Shuangying;ZHAGN Ying;SHENG Jiajia;LI Juan;HE Jingjing;XUAN Henghua;HONG Mingyun(Centre for Reproductive Medicine,Anhui Maternal and Child Health Hospital,Anhui Medical University,Hefei 230001,China)

机构地区：[1]安徽省妇幼保健院/安徽医科大学附属妇幼保健院生殖中心,合肥230001

出　　处：《实用医学杂志》2024年第7期924-929,共6页The Journal of Practical Medicine

基　　金：安徽省高等学校科学研究重点项目(编号:2022AH050785);合肥市2022年度第三批市关键共性技术研发项目(编号:GJ2022SM09);合肥市第七周期医学重点学科建设专科(编号:合卫医秘[2023]72号)。

摘　　要：目的探讨补体C3对冻融胚胎移植(F-ET)妊娠结局的早期预测价值。方法前瞻性收集378个F-ET周期相关资料,依据补体C3预测F-ET妊娠结局的最佳截断值分为A组(补体C3≤1.05)120个周期;B组(补体C3>1.05)258个周期,比较两组结局。分析B组补体C3预测F-ET自然流产的最佳截断值。结果年龄是F-ET妊娠成功的危险因素(P<0.05);补体C3和胚胎类型是F-ET妊娠成功的保护因素(P<0.05)。补体C3对F-ET妊娠结局的受试者工作特征曲线(ROC)曲线下面积为0.702,最佳截断值为1.05 g/L,其预测临床妊娠灵敏度为87.60%、特异度为52.00%。B组临床妊娠率(67.05%)和胚胎着床率(52.75%)明显高于A组,差异有统计学意义(P<0.05)。补体C3早期预测F-ET后自然流产最佳截断值为1.32 g/L,ROC曲线下面积为0.760,灵敏度为69.00%、特异度为81.20%。结论补体C3对早期预测F-ET妊娠结局有一定的临床意义,当补体C3超过1.32 g/L可能会导致自然流产率升高。Objective To investigate the role of complement C3 in early predicting pregnancy outcomes of frozen-thawed embryo transfer(F-ET).Methods A total of 378 F-ET cycles were prospectively collected and divided into group A(complement C3≤1.05,120 cycles)and group B(complement C3>1.05,258 cycles)based on the best cutoff value of complement C3 for predicting F-ET pregnancy outcomes.The outcomes of the two groups were compared,and the best cutoff value of complement C3 for predicting F-ET spontaneous abortion was analyzed in group B.Results Age was a risk factor for successful F-ET pregnancy(P<0.05),and complement C3 and embryo type were protective factors for successful F-ET pregnancy(P<0.05).The area under the receiveroperating characteristic curve(ROC)of complement C3 for predicting F-ET pregnancy outcome was 0.702,and the best cutoff value was 1.05 g/L,with a clinical pregnancy sensitivity of 87.60%and a specificity of 52.00%.The clinical pregnancy rate and embryo implantation rate in group B were both significantly higher than those in group A(67.05%vs.52.75%,P<0.05).The best cutoff value of complement C3 for predicting spontaneous abortion after F-ET was 1.32 g/L,with an area under the ROC curve of 0.760,a sensitivity of 69.00%,and a specificity of 81.20%.Conclusions Complement C3 is of significance in the early prediction of F-ET pregnancy outcome.When complement C3 exceeds the level of 1.32 g/L,it may lead to an increase in the rate of spontaneous abortion.

关 键 词：冻融胚胎移植 临床妊娠率 补体C3 

分 类 号：R711.6[医药卫生—妇产科学]