萘普生与Cu^(2+)对斑马鱼胚胎的联合毒性影响  

Combined toxic effects of Naproxen and Cu^(2+)on zebrafish embryos

作　　者：徐超 姚雨霖 宋继红 张礼治 童新 孙晓慧 牛丽丽 XU Chao;YAO Yulin;SONG Jihong;ZHANG Lizhi;TONG Xin;SUN Xiaohui;NIU Lili(College of Environmental,Zhejiang University of Technology,Hangzhou 310014,China;Hangzhou Environmental Protection Scientific Research Design Co.,Ltd.,Hangzhou 310014,China;College of Medicine and Pharmaceutical Engineering,Taizhou Vocational and Technical College,Taizhou 318000,China;Zhejiang Provincial Ecological Environment Monitoring Center,Hangzhou 310012,China;Institute of Interdisciplinary Sciences,Zhejiang Shuren University,Hangzhou 310015,China)

机构地区：[1]浙江工业大学环境学院,浙江杭州310014 [2]杭州市环境保护科学研究设计有限公司,浙江杭州310014 [3]台州职业技术学院医学与制药工程学院,浙江台州318000 [4]浙江省生态环境监测中心,浙江杭州310012 [5]浙江树人学院交叉科学研究院,浙江杭州310015

出　　处：《浙江工业大学学报》2024年第2期230-236,共7页Journal of Zhejiang University of Technology

基　　金：国家自然科学基金资助项目(C129020344)。

摘　　要：萘普生的广泛使用导致其在环境中持续输入与积累,对生态环境造成潜在的危害。金属离子Cu^(2+)虽然在自然界中普遍存在,但是萘普生和Cu^(2+)的联合毒性效应目前尚不清楚。开展了毒性预实验,根据Cu^(2+)和萘普生96 h LC 50值(毒性单位比4∶1,2∶1,1∶1,1∶2,1∶4)对斑马鱼胚胎进行混合暴露,采用相加指数(AI)法评价联合毒性影响。实验结果表明:萘普生和Cu^(2+)单独暴露对斑马鱼胚胎产生发育毒性,萘普生和Cu^(2+)所有毒性比例的联合暴露实验都对斑马鱼胚胎致死效应表现为拮抗作用。红外光谱结果对比表明:萘普生和Cu^(2+)之间能发生配合反应,所产生的配合物使二元体系联合毒性降低。Due to frequent use,naproxen leads to continuous input and accumulation in the environment,potentially posing harm to the ecosystem.Considering the prevalence of Cu^(2+)in nature,the combined toxicity of naproxen and Cu^(2+)needs further studied.The combined toxic effects were evaluated using the summation index(AI)method with zebrafish embryos exposed to a mixture of Cu^(2+)and naproxen based on their 96 h-LC 50 values(toxicity unit ratios of 4∶1,2∶1,1∶1,1∶2,1∶4).The results indicated that naproxen and Cu^(2+)alone were developmentally toxic to zebrafish embryos,and all toxic ratios of naproxen and Cu^(2+)exhibited antagonistic effects on the lethal effects of zebrafish embryos.Comparison of the IR spectroscopy results revealed that a reaction between naproxen and Cu^(2+)could occur,resulting in a complex that made the binary system less toxic when combined.

关 键 词：斑马鱼 联合毒性 混合暴露 

分 类 号：X592[环境科学与工程—环境工程]