中药干预JAK/STAT信号通路防治糖尿病及其慢性并发症的研究状况  

Research status of traditional Chinese medicine intervening JAK/STAT signaling pathway to prevent and treat diabetes and its chronic complications

作　　者：李涛 杨丽霞[2] 高博 李钦 宋爽 LI Tao;YANG Li-xia;GAO Bo;LI Qin;SONG Shuang(Gansu University of Traditional Chinese Medicine,Clinical College of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Central Laboratory,Gansu Academy of traditional Chinese Medicine,Lanzhou 730050,Gansu Province,China;School of Chinese Medicine,Gansu Health Vocational College,Lanzhou 730207,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃省中医药研究院中心实验室,甘肃兰州730050 [3]甘肃卫生职业学院中医药学院,甘肃兰州730207

出　　处：《中国临床药理学杂志》2024年第5期754-758,共5页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省中医药管理局基金资助项目(GZKP-2021-39)。

摘　　要：2型糖尿病(T2DM)及其慢性并发症,是引起糖尿病患者致残、致死的主要原因,中药治疗本病具有疗效显著、复发率低等优势。近年来运用中医药治疗T2DM的基础研究已取得显著进展,其作用机制可能与中医药调控了Janus激酶(JAK)/信号转导与转录激活因子(STAT)信号通路有关。本文通过阐述JAK/STAT信号通路与T2DM的联系,并归纳总结中药提取物及复方通过调节该信号通路干预T2DM的研究进展,以期为T2DM治疗药物的临床应用及新药物研发提供参考。Type 2 diabetes mellitus(T2DM) and its chronic complications are the main causes of disability and death in diabetic patients.Traditional Chinese medicine has the advantages of significant curative effect and low recurrence rate.In recent years,the basic research on the treatment of T2DM with traditional Chinese medicine has made significant progress,and its mechanism may be related to the regulation of Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signal pathway by traditional Chinese medicine.This paper expounds the relationship between JAK/STAT signaling pathway and T2DM,and summarizes the research progress of traditional Chinese medicine extract and compound prescription in the intervention of T2DM by regulating this signaling pathway,in order to provide references for the clinical application of T2DM therapeutics and the development of new drugs.

关 键 词：2型糖尿病及其慢性并发症 Janus激酶/信号转导和转录激活因子信号通路 中药 

分 类 号：R28[医药卫生—中药学]