Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing  

作　　者：Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed Albati M.A.El-Morsy A.A.Menazea 

机构地区：[1]Department of Health Informatics,College of Public Health and Health Informatics,University of Ha'il,Ha'il,Saudi Arabia [2]Department of Surgery,College of Medicine,University of Ha'il,Ha'il,Saudi Arabia [3]Department of Public Health,College of Public Health and HealthInformatics,HalUniversity,Ha'il,2440,Saudi Arabi [4]Food Control Department,Faculty of Veterinary Medicine,Zagazig University,Zagazig,44519,Egypt [5]Applied Science Research Center,Applied Science Private University,Amman,541350,Jordan [6]College of Shariah and Law,Ha'il University,Ha'il,2440,Saudi Arabia [7]College of Science and Humanities in Al-Kharj,Physics Department,Plasma Technology and Material Science Unit,Prince Sattam Bin Abdulaziz University,Al-kharj,11942,Saudi Arabia [8]Physics Department,Faculty of Science,University of Damitta,New Damietta,34517.Egyp [9]Spectroscopy Department,Physics Research Institute,National Research Centre,Dokki,12622,Giza,Egypt

出　　处：《Journal of Rare Earths》2024年第3期555-561,I0005,共8页稀土学报（英文版）

基　　金：funded by the Scientific Research Deanship at University of Ha'il,Saudi Arabia through project number RG-21169。

摘　　要：Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关 键 词：Wound healing Wound dressing POLYCAPROLACTONE Sm_(2)O_(3) Cr_(2)O_(3) Rare earths 

分 类 号：R318.08[医药卫生—生物医学工程]