海派中医颜氏麻蒲颗粒治疗肝阳上亢型急性脑梗死60例  

Clinical effect of Yan’s Mapu granules of Shanghai-style Traditional Chinese Medicine in treatment of acute cerebral infarction with upper hyperactivity of liver Yang:An analysis of 60 cases

作　　者：丁晨云[1] 壮新军 雷运贵 DING Chenyun;ZHUANG Xinjun;LEI Yungui(Danyang Hospital of Traditional Chinese Medicine,Danyang 212300,Jiangsu,China)

机构地区：[1]丹阳市中医院,江苏丹阳212300

出　　处：《湖南中医杂志》2024年第2期5-9,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：江苏省镇江市社会发展指导性科技计划项目(FZ2021008)。

摘　　要：目的:观察海派中医颜氏麻蒲颗粒对肝阳上亢型急性脑梗死的临床疗效。方法:选取肝阳上亢型急性脑梗死患者120例,将其随机分为治疗组和对照组,每组各60例。2组基础治疗均为西医脑梗死规范治疗,治疗组加服颜氏麻蒲颗粒,对照组加服天麻钩藤饮,2组疗程均为30 d。观察2组中医证候积分、美国国立卫生研究院卒中量表(NIHSS)评分、血压、炎症指标、颈部血管彩超最大斑块面积、血脂水平和中医证候疗效。结果:中医证候疗效总有效率治疗组为98.3%(59/60),对照组为85.0%(51/60),2组比较,差异有统计学意义(P<0.01)。在下调中医证候积分、NIHSS评分、血压指标方面,治疗组比对照组效果更佳(P<0.01);在调控炎症指标超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)、血脂水平、颈部血管彩超最大斑块面积方面,治疗组比对照组更优(P<0.05)。结论:海派中医颜氏麻蒲颗粒治疗肝阳上亢型急性脑梗死疗效显著,可资临床借鉴。Objective:To investigate the clinical effect of Yan's Mapu granules of Shanghai-style Traditional Chinese Medicine in the treatment of acute cerebral infarction with upper hyperactivity of liver Yang.Methods:A total of 120 patients with acute cerebral infarction with upper hyperactivity of liver Yang were selected and randomly divided into treatment group and control group,with 60 patients in each group.In addition to the basic Western standard treatment of cerebral infarction,the patients in the treatment group were given Yan's Mapu granules,and those in the control group were given Tianma Gouteng decoction;the course of treatment was 30 days for both groups.The two groups were observed in terms of TCM syndrome score,National Institutes of Health Stroke Scale(NIHSS) score,blood pressure,inflammation indicators,largest plaque area on color Doppler ultrasound for cervical vessels,blood lipid levels,and treatment outcome of TCM syndrome.Results:There was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group [98.3%(59/60) vs 85.0%(51/60),P<0.01].Compared with the control group,the treatment group had significantly greater reductions in TCM syndrome score,NIHSS score,and blood pressure parameters and significantly better improvements in the inflammation indicators high-sensitivity C-reactive protein and interleukin-6,blood lipid levels,and largest plaque area on color Doppler ultrasound for cervical vessels(P<0.05).Conclusion:Yan's Mapu granules of Shanghai-style Traditional Chinese Medicine has a marked clinical effect in the treatment of acute cerebral infarction with upper hyperactivity of liver Yang and thus provides a reference for clinical practice.

关 键 词：缺血性卒中 肝阳上亢 颜氏麻蒲颗粒 海派中医 

分 类 号：R277.733[医药卫生—中医学]