五虎汤联合布地奈德混悬液治疗痰热壅肺型喘息性支气管炎59例  

Clinical effect of Wuhu decoction combined with budesonide suspension in treatment of asthmatic bronchitis with phlegm-heat obstructing the lung:An analysis of 59 cases

作　　者：杨惠 王孟清[1] 戎宽 YANG Hui;WANG Mengqing;RONG Kuan(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China;Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Changsha 410006,Hunan,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南省中西医结合医院,湖南长沙410006

出　　处：《湖南中医杂志》2024年第2期14-17,43,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省临床医疗技术创新引导项目(2021SK51405);湖南省卫生健康委科研项目(D202306018057);全国名老中医药专家王孟清传承工作室建设项目。

摘　　要：目的:观察五虎汤联合布地奈德混悬液治疗痰热壅肺型喘息性支气管炎的临床疗效。方法:将116例痰热壅肺型喘息性支气管炎患儿随机分为治疗组(59例)和对照组(57例)。对照组采用布地奈德混悬液雾化吸入治疗,治疗组在对照组的基础上加服五虎汤治疗。治疗7 d后,比较2组临床症状或体征(发热、咳嗽、呼吸困难、气喘、湿啰音)消失时长、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、炎症因子[白细胞介素-5(IL-5)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)]水平及不良反应发生情况。结果:总有效率治疗组为93.22%(55/59),对照组为77.19%(44/57),2组比较,差异有统计学意义(P<0.05)。治疗组临床症状或体征消失时长均短于对照组(P<0.01)。2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IL-5、IL-6水平均较治疗前降低,CD8^(+)、血清IL-10、IFN-γ水平均较治疗前升高,且治疗组改善幅度较对照组更大(P<0.01)。不良反应发生率治疗组为8.47%(5/59),对照组为17.54%(10/57),差异有统计学意义(P<0.05)。结论:五虎汤联合布地奈德混悬液雾化吸入治疗痰热壅肺型喘息性支气管炎,不仅能够在短时间内改善症状及体征,降低肺部炎症反应,提高患儿机体免疫功能,而且安全有效,值得临床推广。Objective:To investigate the clinical effect of Wuhu decoction combined with budesonide suspension in the treatment of asthmatic bronchitis with phlegm-heat obstructing the lung.Methods:A total of 116 children with asthmatic bronchitis with phlegm-heat obstructing the lung were randomly divided into treatment group with 59 children and control group with 57 children.The children in the control group received aerosol inhalation of budesonide suspension,and those in the treatment group received Wuhu decoction in addition to the treatment in the control group.After 7 days of treatment,the two groups were compared in terms of the time to disappearance of clinical symptoms or signs(pyrexia,cough,dyspnea,short of breath,and moist rales),T lymphocyte subsets(CD3~+,CD4~+,CD8~+,CD4~+/CD8~+),inflammatory factors [interleukin-5(IL-5),interleukin-6(IL-6),interleukin-10(IL-10),and interferon gamma(IFN-γ)],and adverse reactions.Results:There was a significant difference in overall response rate between the treatment group and the control group [93.22%(55/59) vs 77.19%(44/57),P<0.05].Compared with the control group,the treatment group had a significantly shorter time to disappearance of clinical symptoms or signs(P<0.01).After treatment,both groups had significant reductions in CD3~+,CD4~+,CD4~+/CD8~+,IL-5,and IL-6 and significant increases in CD8~+ and the serum levels of IL-10 and IFN-γ,and the treatment group had significantly greater improvements than the control group(P<0.01).The treatment group had a significantly lower incidence rate of adverse reactions than the control group [8.47%(5/59) vs 17.54%(10/57),P<0.05].Conclusion:In the treatment of asthmatic bronchitis with phlegm-heat obstructing the lung,Wuhu decoction combined with aerosol inhalation of budesonide suspension can improve symptoms and signs within a short period of time,reduce pulmonary inflammatory response,and improve immune function,with good efficacy and safety,and therefore,it holds promise for clinical application.

关 键 词：喘息性支气管炎 五虎汤 布地奈德混悬液 

分 类 号：R259.622.5[医药卫生—中西医结合]