基于数据挖掘探析张奇文治疗癫痫的用药规律  

Medication rule of Zhang Qiwen in treatment of epilepsy:A study based on data mining

作　　者：王默然[1] 朱士高[1] 刘茜茜[1] 罗小红 WANG Moran;ZHU Shigao;LIU Qianqian;LUO Xiaohong(Weifang Hospital of Traditional Chinese Medicine,Weifang 261000,Shandong,China)

机构地区：[1]潍坊市中医院,山东潍坊261000

出　　处：《湖南中医杂志》2024年第2期18-22,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：山东省潍坊市中医药科研项目(WFZYY2022-1-005)。

摘　　要：目的:基于数据挖掘技术探析全国名中医张奇文治疗癫痫的用药规律。方法:收集1998年9月1日至2019年9月30日张奇文治疗癫痫的医案,对医案中的数据进行规范化处理,构建数据库,应用古今医案云平台V2.3.5对中药使用频次、四气五味、功效归经、关联、聚类等进行分析,并总结临床经验。结果:共筛选出40首处方,中药120味。排前10位的中药分别为全蝎、蜈蚣、僵蚕、炙甘草、麦芽、山楂、钩藤、羚羊角、珍珠、牛黄,药性以平、温为主,药味主要为甘、辛、苦,主要归肝、肺、脾经,功效以通络止痛、攻毒散结、息风镇痉等为主。关联组合支持度高的组合为全蝎-蜈蚣、全蝎-僵蚕、僵蚕-蜈蚣、钩藤-全蝎、钩藤-蜈蚣。结论:张奇文治疗癫痫标本兼顾,治标重视息风,治本重视健脾。Objective:To investigate the medication rule of National Famous TCM Doctor Zhang Qiwen in the treatment of epilepsy based on data mining.Methods:Medical records of epilepsy treated by Zhang Qiwen from September 1st,1998 to September 30th,2019 were collected,and standardized processing was performed for the data in the medical records to construct a database.Cloud Platform of Ancient and Modern Medical Records V2.3.5 was used to analyze frequency of use,four properties and five tastes,function,and meridian entry and perform association rule analysis and cluster analysis,and clinical experience was summarized.Results:A total of 40 prescriptions were obtained,involving 120 TCM drugs.The top 10 TCM drugs were scorpion,centipede,Bombyx batryticatus,Radix Glycyrrhizae Preparata,malt,hawthorn fruit,Uncaria,Cornu Saigae Tataricae,pearl,and bezoar.Most drugs were neutral or warm in nature and mainly had a sweet,pungent or bitter taste,and they mainly entered the liver,lung,and spleen meridians.The main functions included dredging collaterals and relieving pain,counteracting toxic substances and resolving static blood,and extinguishing wind and relieving spasm.The drug combinations with the high degree of support were scorpion-centipede,scorpion-Bombyx batryticatus,Bombyx batryticatus-centipede,Uncaria-scorpion,and Uncaria-centipede.Conclusion:Zhang Qiwen addresses both the symptoms and root causes in the treatment of epilepsy,with a focus on extinguishing wind in symptomatic treatment and strengthening the spleen in radical treatment.

关 键 词：癫痫 张奇文 数据挖掘 用药规律 

分 类 号：R277.721[医药卫生—中医学]