桂枝茯苓丸加味联合来曲唑治疗多囊卵巢综合征所致不孕症临床研究  

Clinical Study on Modified Guizhi Fuling Pills Combined with Letrozole for Infertility Caused by Polycystic Ovary Syndrome

作　　者：朱丽萍 金方 张琳[2] 陈盼[2] 郑顺杰[2] ZHU Liping;JIN Fang;ZHANG Lin;CHEN Pan;ZHENG Shunjie(Jinhua Maternal&Child Health Care Hospital,Jinhua Zhejiang 321000 China;Jinhua Municipal Central Hospital,Jinhua Zhejiang 321000,China)

机构地区：[1]金华市妇幼保健院,浙江金华321000 [2]金华市中心医院,浙江金华321000

出　　处：《新中医》2024年第4期5-9,共5页New Chinese Medicine

摘　　要：目的:观察桂枝茯苓丸加味联合来曲唑治疗肾虚血瘀型多囊卵巢综合征所致不孕症的临床疗效。方法:选取96例多囊卵巢综合征所致不孕症肾虚血瘀证患者,按随机数字表法分为对照组和观察组,每组48例。对照组予以来曲唑片治疗,观察组在对照组基础上予以桂枝茯苓丸加味治疗。1个月经周期为1个疗程,2组均治疗3个疗程。比较2组临床疗效、性激素指标、凝血指标、脂代谢指标及不良反应发生率。结果:治疗后随访1年,观察组总有效率95.83%,高于对照组81.25%(P<0.05)。治疗后,2组黄体生成素(LH)/卵泡刺激素(FSH)值及血清LH、睾酮(T)、纤维蛋白原(FIB)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平均较治疗前降低(P<0.05),观察组LH/FSH值及血清LH、T、FIB、TC、LDL-C、TG水平均低于对照组(P<0.05)。2组血清凝血酶时间(PT)、凝血酶原时间(TT)均较治疗前增加(P<0.05),观察组血清PT、TT均长于对照组(P<0.05)。2组血清高密度脂蛋白胆固醇(HDL-C)水平均较治疗前升高(P<0.05),观察组血清HDL-C水平高于对照组(P<0.05)。观察组不良反应发生率8.33%,与对照组12.50%比较,差异无统计学意义(P>0.05)。结论:桂枝茯苓丸加味联合来曲唑治疗肾虚血瘀型多囊卵巢综合征所致不孕症疗效确切,能纠正性激素紊乱,改善凝血及脂代谢指标,安全性好。Objective:To observe the clinical effect of the therapy of modified Guizhi Fuling Pills combined with Letrozole on infertility caused by polycystic ovary syndrome.Methods:A total of 96 patients with infertility caused by polycystic ovary syndrome with syndrome of kidney deficiency with blood stasis were selected and divided into the control group and the observation group,with 48 cases in each group.The control group was given Letrozole Tablets for treatment,and the observation group was additionally treated with modified Guizhi Fuling Pills based on the treatment of the control group.With one menstrual cycle as a course of treatment,both groups were treated for three courses.The clinical effects,indexes of sexual hormones,coagulation markers,lipid metabolism indexes and incidence of adverse reactions were compared between the two groups.Results:With follow-up for 1 year after treatment,the total effective rate was 95.83%in the observation group,higher than that of 81.25%in the control group(P<0.05).After treatment,the ratio of luteinizing hormone(LH)and follicle stimulation hormone(FSH),and levels of serum LH,testosterone (T),fibrinogen (FIB),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C)and triglyceride (TG) in both groups were decreased when compared with those before treatment (P<0.05),and the ratio of LH/FSH and levels of serum LH,T,FIB,TC,LDL- C and TG were lower thanthose in the control group (P<0.05). The serum prothrombin time (PT) and thrombin time (TT) in both groupswere increased when compared with those before treatment (P<0.05),and the serum PT and TT in theobservation group were longer than those in the control group (P<0.05). The levels of serum high densitylipoprotein cholesterol (HDL-C) in both groups were increased when compared with those before treatment(P<0.05),and the serum HDL-C level in the observation group was higher than that in the control group(P<0.05). The incidence of adverse reactions was 8.33% in the observation group and 12.50% in the controlgroup,there being

关 键 词：多囊卵巢综合征 不孕症 肾虚血瘀型 桂枝茯苓丸 来曲唑 性激素 凝血 脂代谢 

分 类 号：R271.14[医药卫生—中医妇科学]