血必净注射液辅助治疗重症肺炎疗效观察及对炎症因子水平的影响  

Curative Effect of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effect on Levels of Inflammatory Factors

作　　者：袁灵敏 李群 YUAN Lingmin;LI Qun(Intensive Care Unit,Longyou People's Hospital,Longyou Zhejiang 324400,China;Department of Chinese medicine,Longyou People's Hospital,Longyou Zhejiang 324400,China)

机构地区：[1]龙游县人民医院重症医学科,浙江龙游324400 [2]龙游县人民医院中医科,浙江龙游324400

出　　处：《新中医》2024年第4期48-52,共5页New Chinese Medicine

摘　　要：目的:观察血必净注射液辅助治疗重症肺炎的临床疗效及对血清炎症因子水平的影响。方法:将84例重症肺炎患者按随机数字表法分为对照组和观察组各42例。对照组在常规对症治疗基础上联合注射用亚胺培南西司他丁钠治疗,观察组在对照组的基础上加用血必净注射液治疗。比较2组临床疗效、血气指标[血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、血液酸碱度(pH)]、血清炎症因子[白细胞介素-6 (IL-6)、白细胞介素-10 (IL-10)、C-反应蛋白(CRP)]水平及并发症发生率。结果:治疗后,观察组总有效率为95.24%,对照组为80.95%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组PaO_(2)水平较治疗前升高(P<0.05),PaCO_(2)、pH水平较治疗前降低(P<0.05);且观察组PaO_(2)水平高于对照组(P<0.05),PaCO_(2)、pH水平低于对照组(P<0.05)。治疗后,2组IL-6、IL-10、CRP水平均较治疗前降低(P<0.05),且观察组上述各项指标均低于对照组(P<0.05)。治疗后,观察组并发症发生率为9.52%,对照组为26.19%,2组比较,差异有统计学意义(P<0.05)。结论:在西医常规治疗的基础上,注射用亚胺培南西司他丁钠联合血必净注射液治疗重症肺炎效果显著,可改善患者血气状态,有效抑制机体炎症反应,减少并发症。Objective:To observe the clinical effect of Xuebijing Injection in adjuvant treatment of severe pneumonia and its effect on the levels of serum inflammatory factors.Methods:A total of 84 cases of patients with severe pneumonia were divided into the control group and the observation group according to the random number table method,with 42 cases in each group.The control group was treated with Imipenem-Cilastatin Sodium for Injection based on routine symptomatic treatment,and the observation group was additionally treated with Xuebijing Injection based on the treatment of the control group.Clinical effects,blood gas indexes[partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),and blood pH],levels of serum inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),and Creactive protein(CRP)]and the incidence of complications were compared between the two groups.Results:After treatment,the total effective rate was 95.24% in the observation group and 80.95%in the control group,the difference being significant(P<0.05).After treatment,PaO_(2) levels in the two groups were increased when compared with those before treatment(P<0.05),and the levels of PaCO_(2) and pH were decreased when compared with those before treatment(P<0.05);the PaO_(2) level in the observation group was higher than that in the control group(P<0.05),and the levels of PaCO2 and pH were lower than those in the control group(P<0.05).After treatment,the levels of IL-6,IL-10 and CRP in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the observation group were lower than those in the control group(P<0.05).After treatment,the incidence of complications was 9.52% in the observation group and 26.19% in the control group,the difference being significant(P<0.05).Conclusion:Based on routine treatment of western medicine,Imipenem-Cilastatin Sodium for Injection combined with Xuebijing Injection for severe pneumonia can improve blood gas status,effectively inhibit inflammator

关 键 词：重症肺炎 注射用亚胺培南西司他丁钠 血必净注射液 炎症因子 并发症 

分 类 号：R563.1[医药卫生—呼吸系统]