复方红藤合剂联合屈螺酮炔雌醇片、妇炎康胶囊治疗宫腔镜子宫内膜息肉切除术后临床研究  

Clinical Study of Compound Hongteng Mixture Combined with Drospirenone and Ethinylestradiol Tablets and Fuyankang Capsules for Patients After Hysteroscopic Endometrial Polypectomy

作　　者：李永陈 钱敏英 李曼曼 LI Yongchen;QIAN Minying;LI Manman(Chun'an County Maternal and Child Health Care Hospital,Chun'an Zhejiang 311700,China)

机构地区：[1]淳安县妇幼保健院,浙江淳安311700

出　　处：《新中医》2024年第4期74-79,共6页New Chinese Medicine

摘　　要：目的:观察复方红藤合剂联合屈螺酮炔雌醇片、妇炎康胶囊治疗宫腔镜子宫内膜息肉切除术后患者的临床效果。方法:选取80例湿热血瘀型子宫内膜息肉患者,随机分为对照组和联合组各40例。2组均行宫腔镜子宫内膜息肉切除术治疗,术后均采用妇炎康胶囊与屈螺酮炔雌醇片治疗,联合组加予复方红藤合剂治疗。2组疗程均为3个月经周期,随访3个月。治疗前后评定中医证候评分,观察月经恢复情况(记录经期、月经量、子宫内膜厚度),检测性激素指标[雌二醇(E2)、黄体生成素(LH)、卵泡生成激素(FSH)]、炎症因子指标[C-反应蛋白(CRP)、白细胞介素-4 (IL-4)]。统计临床疗效、月经改善率、不良反应发生率及子宫内膜息肉复发率。结果:治疗后,联合组临床疗效总有效率(95.00%)高于对照组(75.00%),差异有统计学意义(P<0.05)。2组中医证候积分均较治疗前减少(P<0.05)。联合组中医证候积分低于对照组(P<0.05)。2组经期均较治疗前缩短,月经量均较治疗前减少,子宫内膜厚度均薄于治疗前,差异均有统计学意义(P<0.05)。联合组经期短于对照组,月经量少于对照组,子宫内膜厚度薄于对照组,差异均有统计学意义(P<0.05)。联合组月经改善率高于对照组(P<0.05)。2组血清E2、LH、FSH水平均较治疗前降低(P<0.05)。联合组血清E2、LH、FSH水平均低于对照组(P<0.05)。2组血清CRP水平均较治疗前降低,血清IL-4水平均较治疗前升高,差异均有统计学意义(P<0.05)。联合组血清CRP水平低于对照组,血清IL-4水平高于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。随访3个月,联合组复发率低于对照组(P<0.05)。结论:采用复方红藤合剂联合屈螺酮炔雌醇片、妇炎康胶囊治疗宫腔镜子宫内膜息肉切除术后患者,可减少月经量,调节性激素水平,减轻炎症反应,有效预防息肉复发,安全有Objective:To observe the clinical effect of the therapy of Compound Hongteng Mixture combined with Drospirenone and Ethinylestradiol Tablets and Fuyankang Capsules on patients after hysteroscopic endometrial polypectomy.Methods:A total of 80 patients with endometrial polyps of dampheat with blood stasis type were selected and randomly divided into the control group and the combination group,with 40 cases in each group.The two groups were given hysteroscopic endometrial polypectomy for treatment,after which the two groups were treated with Drospirenone and Ethinylestradiol Tablets and Fuyankang Capsules and the combination group was additionally treated with Compound Hongteng Mixture.The two groups were treated for three menstrual cycles and followed up for 3 months.The traditional Chinese medicine(TCM)syndrome scores were evaluated before and after treatment;the menstruation recovery was observed by recording the menstrual period,menstrual volume and endometrial thickness;the levels of sex hormones,including estradiol(E2),luteinizing hormone(LH)and follicle-stimulating hormone(FSH),and of inflammatory factors,including C-reactive protein(CRP)and interleukin-4(IL-4)were detected.The clinical effects,improvement rate of menstruation,incidence of adverse reactions and recurrence rate of endometrial polyps were counted.Results:After treatment,the total clinical effective rate was 95.00%in the combination group,higher than that of 75.00%in the control group,the difference being significant(P<0.05).The TCM syndrome scores in the two groups were decreased when compared with those before treatment,and the TCM syndrome score in the combination group was lower than that in the control group(P<0.05).The menstrual period in the two groups were shortened when compared with those before treatment,the menstrual volume were reduced when compared with those before treatment,and the endometrial thickness were thinner than those before treatment,differences being significant(P<0.05).The menstrual period in the combination group was

关 键 词：子宫内膜息肉 宫腔镜子宫内膜息肉切除术 湿热血瘀证 复方红藤合剂 性激素 炎症因子 复发 

分 类 号：R713.4[医药卫生—妇产科学]