儿童急性喉炎中医证素及发生喉梗阻危险因素相关性分析  

Correlation Analysis of Traditional Chinese Medicine Syndrome Elements and Risk Factors of Laryngeal Obstruction in Children with Acute Laryngitis

作　　者：谢美玉 王浩 黄钢花[3] XIE Meiyu;WANG Hao;HUANG Ganghua(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;Guangzhou Medical University,Guangzhou Guangdong 511436,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州医科大学,广东广州511436 [3]广州中医药大学第一附属医院,广东广州510405

出　　处：《新中医》2024年第4期92-97,共6页New Chinese Medicine

摘　　要：目的:探讨儿童急性喉炎的中医证素及儿童急性喉炎发生喉梗阻危险因素的相关性分析。方法:收集2011年8月—2023年4月在广州中医药大学第一附属医院儿科住院治疗的255例急性喉炎患儿的病历资料(基本资料、四诊信息、白细胞数值、喉梗阻情况等),采取证素辨证法确定中医证素,将结果导入SPSS Modeler18.0软件,采用Apriori算法进行关联规则分析,证素之间的关系以复杂网络图表示,采取系统聚类分析法分析不同证素组合情况,并将相关因素进行二元Logistic回归分析。结果:共纳入255例患儿,其中以婴幼儿居多。255例患儿共提取证素14个,包括病位证素4个和病性证素10个。病位证素为肺、表、心神、小肠,病性证素中热、外风、痰为高频证素,证素组合以肺+表+热+外风占比最高。证素组成以肺、表、热为中心,形成了肺-热、表-肺、表-热、外风-肺、外风-表、外风-热、肺-痰、热-痰8组强链接。取类间距为24,可取得2个聚类单元,其中病位证素肺、表与病性证素热、血热、外风、痰、饮、寒为一类,病位证素心神、小肠与病性证素毒、闭、动风、湿为一类。证素饮对急性喉炎患儿发生喉梗阻的影响有统计学意义(P<0.05)。证素表、外风、闭、血热及白细胞增高对急性喉炎患儿发生喉梗阻的影响无统计学意义(P>0.05)。结论:儿童急性喉炎发病是因风热、风寒之邪侵犯肺脏或痰热壅盛,阻遏肺气,肺失宣降,声门开阖不利所致。证素饮是急性喉炎患儿发生喉梗阻的危险因素。Objective:To explore the correlation analysis of traditional Chinese medicine(TCM)syndrome elements and correlation analysis of risk factors for the development of laryngeal obstruction in children with acute laryngitis.Methods:Medical records of 255 cases of children with acute laryngitis hospitalized in the Department of Pediatrics of The First Affiliated Hospital of Guangzhou University of Chinese Medicine from August 2011 to April 2023 were collected(basic data,the four examinations,leukocyte counts,laryngeal obstruction,etc.).TCM syndrome elements were determined based on syndrome differentiation,and the results were imported into SPSS Modeler 18.0 software.The Apriori algorithm was used to analyze the association rules,and the relationship among them was represented by complex network diagram.The combination of different syndrome elements was analyzed by systematic cluster analysis,and the related factors were analyzed by binary logistic regression.Results:A total of 255 cases of children were included,most of whom were infants.A total of 14 syndrome elements were extracted from 255 cases of children;there were 4 syndrome elements on location of disease,namely lung,exterior,heart spirit and small intestine;there were 10 syndrome elements on nature of disease,among which heat,external wind and phlegm had high frequency,and the combination of syndrome elements with lung,exterior,heat and external wind accounted for the highest proportion.The composition of syndrome elements centered on lung,exterior and heat,and formed eight strong links of lung-heat,exterior-lung,exterior-heat,external wind-lung,external wind-exterior,external windheat,lung-phlegm,and heat-phlegm.With a class interval of 24,2 cluster units could be obtained,among which the syndrome elements on location of disease like lung and exterior and the syndrome elements on nature of disease like heat,blood heat,external wind,phlegm,fluid retention and cold were classified as one class,while the syndrome elements on location of disease like heart spir

关 键 词：急性喉炎 儿童 中医证素 饮 喉梗阻 危险因素 相关性 

分 类 号：R272[医药卫生—中医儿科学]