参蝎止痛胶囊联合董氏奇穴对寒湿痹阻型膝骨关节炎患者的临床疗效  

Clinical effects of Shenxie Zhitong Capsules combined with DONG’s Extraordinary Points on patients with knee osteoarthritis of Cold-Dampness Obstruction Pattern

作　　者：李莉[1] 詹红生[1] LI Li;ZHAN Hong-sheng(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中成药》2024年第3期821-825,共5页Chinese Traditional Patent Medicine

基　　金：上海市2020年度“科技创新行动计划”医学创新研究专项项目(20MC1920600)。

摘　　要：目的 探讨参蝎止痛胶囊联合董氏奇穴对寒湿痹阻型膝骨关节炎患者的临床疗效。方法 80例患者随机分为对照组和观察组,每组40例,对照组给予董氏奇穴,观察组在对照组基础上加用参蝎止痛胶囊,疗程1个月。检测临床疗效、中医证候评分、LKSS评分、WOMAC评分、NRS评分、AIMS2-SF评分、sIL-4R、TNF-α、HMGBl、TLR-4、BALP、BGP、β-CTX变化。结果 观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候评分、WOMAC评分、NRS评分、sIL-4R、TNF-α、HMGBl、TLR-4、β-CTX降低(P<0.05),LKSS评分、AIMS2-SF评分、BALP、BGP升高(P<0.05),以观察组更明显(P<0.05)。结论 参蝎止痛胶囊联合董氏奇穴可抑制寒湿痹阻型膝骨关节炎患者机体炎症反应,改善骨代谢,缓解膝关节疼痛及临床症状。AIM To explore the clinical effects of Shenxie Zhitong Capsules combined with DONG’s Extraordinary Points on patients with knee osteoarthritis of Cold-Dampness Obstruction Pattern.METHODS Eighty patients were randomly assigned into control group(40 cases)for 1-month intervention of DONG’s Qi Point,and observation group(40 cases)for 1-month intervention of both Shenxie Zhitong Capsules and DONG’s Qi Point.The changes in clinical effects,TCM syndrome scores,LKSS score,WOMAC score,NRS score,AIMS2-SF score,sIL-4R,TNF-α,HMGBl,TLR-4,BALP,BGP andβ-CTX were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,WOMAC score,NRS score,sIL-4R,TNF-α,HMGBl,TLR-4,β-CTX(P<0.05),and increased LKSS score,AIMS2-SF score,BALP,BGP(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients of Cold-Dampness Obstruction Pattern,Shenxie Zhitong Capsules combined with DONG’s Extraordinary Points can inhibit body inflammatory responses,improve bone metabolism,and relieve knee pain and clinical symptoms.

关 键 词：参蝎止痛胶囊 董氏奇穴 膝骨关节炎 寒湿痹阻 

分 类 号：R287[医药卫生—中药学]