基于CCTA图像的冠周脂肪参数与冠脉粥样硬化程度的相关性研究  

Study on the Correlation between Pericoronary Fat Parameters and Coronary Atherosclerosis Degree Based on CCTA Images

作　　者：高鹏程 贾标 罗先富 GAO Peng-cheng;JIA Biao;LUO Xian-fu(Yangzhou University College of Clinical Medicine,Jiangsu 225000,China;Gaoyou People's Hospital,Jiangsu 225600,China;Northern Jiangsu People's Hospital,Jiangsu 225000,China)

机构地区：[1]扬州大学临床医学院,江苏225000 [2]高邮市人民医院,江苏225600 [3]江苏省苏北人民医院,江苏225000

出　　处：《影像技术》2024年第2期13-19,共7页Image Technology

摘　　要：目的:研究基于冠状动脉CT血管造影图像(CCTA)测量冠状动脉周围脂肪(PCAT)的相关参数与冠状动脉粥样硬化之间的关系。方法:回顾性收集142例于苏北人民医院行CCTA检查并同期行冠脉造影检查的符合条件的患者,根据冠脉造影结果将患者分为正常组和冠心病组,冠心病组进一步分为轻度、中度以及重度亚组。基于CCTA图像利用一种半自动化的医学影像分析软件测量右冠状动脉(RCA)、左前降支(LAD)以及左回旋支(LCX)近段40mm的冠脉周围脂肪衰减指数(FAI)以及PCAT体积(以下简称体积),比较正常组与冠心病组以及各亚组间PCAT相关参数的差异,并分析PCAT相关参数与冠状动脉粥样硬化程度之间的相关性。结果:冠心病组的RCAFAI、LAD-FAI以及LCX-FAI均高于正常组(P<0.01);冠心病组中对于RCA-FAI重度组>中度组>轻度组,对于LADFAI重度组和中度组均大于轻度组,对于LCX-FAI重度组均大于中度组和轻度组,对于LCX-体积重度组小于轻度组。结论:RCA-FAI、LAD-FAI、LCX-FAI以及LCX体积与冠状动脉粥样硬化程度相关,并且RCA-FAI是冠脉粥样硬化严重程度的独立预测因子。Objective:To investigate the relationship between pericoronary adipose tissue(PCAT)re⁃lated parameters and coronary atherosclerosis based on coronary CT angiography(CCTA).Methods:142 eligible patients undergoing CCTA examination and coronary angiography examination were retrospec⁃tively collected.The patients were divided on coronary angiography results into normal group and coro⁃nary heart disease(CHD)group,and the CHD group was divided into mild,moderate and severe sub⁃groups.Pericoronary fat attenuation index(FAI)and PCAT volume using a semi-automated medical imag⁃ing analysis software to measure the right coronary artery(RCA),left anterior descending artery(LAD)and left circumflex(LCX)at 40mm,compare the differences between the normal group and coronary heart disease group and subgroups,and analyze the correlation between PCAT parameters and the degree of coronary atherosclerosis.Results:RCA-FAI,LAD-FAI and LCX-FAI in CAD group were higher than normal group(P<0.01);In the CHD group,for RCA-FAI,severe group was higher than moderate,and moderate than mild;for LAD-FAI,severe and moderate groups were higher than mild;for LCX-FAI,se⁃vere group was higher than moderate and mild;for LCX-volume,severe group was less than mild.Conclu⁃sions:RCA-FAI,LAD-FAI,LCX-FAI,and LCX volume were associated with the degree of coronary ath⁃erosclerosis,and RCA-FAI was an independent predictor of the severity of coronary atherosclerosis.

关 键 词：冠状动脉粥样硬化 冠状动脉CT血管成像 脂肪衰减指数 

分 类 号：R541.4[医药卫生—心血管疾病]