rhEGF联合bFGF应用于感染性慢性难愈性创面的临床疗效  

Effect of rhEGF combined with bFGF on treatment of infectious chronic refractory wounds

作　　者：梅钰莹 许腊梅 刘蓉 许娟娟 MEI Yu-ying;XU La-mei;LIU Rong;XU Juan-juan(First Affiliated Hospital of Nanjing Medical University(Jiangsu Provincial People's Hospital),Nanjing,Jiangsu210003,China)

机构地区：[1]南京医科大学第一附属医院(江苏省人民医院)整形烧伤科,江苏南京210003

出　　处：《中华医院感染学杂志》2024年第6期882-886,共5页Chinese Journal of Nosocomiology

基　　金：上海王正国创伤医学发展基金会基金资助项目(WZGF20200101);江苏省科研基金资助项目(2021JH031400)。

摘　　要：目的 探讨重组人表皮生长因子(rhEGF)联合碱性成纤维细胞生长因子(bFGF)应用于感染性慢性难愈性创面的临床效果。方法 选取2021年7月—2023年3月来南京医科大学第一附属医院治疗的120名慢性难愈性创面患者为受试者,随机分为研究组60例和对照组60例,研究组采用rhEGF联合bFGF治疗,对照组患者仅使用rhEGF治疗,比较两组治疗前后炎症指标、疼痛评分、伤口分泌物细菌培养及创面肉芽组织生长情况、愈合时间等。结果 两组患者一般资料比较无统计学差异,具有可比性。两组患者治疗前炎症指标结果对比无统计学差异,治疗3 d后炎症指标研究组更低(P<0.05);两组患者在治疗后3、7、14 d的疼痛评分比较中,研究组疼痛评分更低(P<0.05);而两组伤口分泌物的细菌培养结果在7 d和14 d显示有统计学差异(P <0.05),研究组细菌培养阳性率更低(P<0.05);在治疗后7 d和14 d,对比创面肉芽组织生长情况,研究组分数更低,两组间结果有统计学差异(P<0.05),前3 d组间结果无统计学差异。患者创面愈合时间研究组短于对照组(P<0.05)。结论 rhEGF联合bFGF治疗有助于缓解伤口的疼痛和炎性反应,显著降低创口的细菌感染,并能提升创口的肉芽生长速度,愈合速度更快。该方法临床疗效良好,且无任何药物副作用,有较好的临床应用价值。OBJECTIVE To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)com-bined with basic fibroblast growth factor(bFGF)on treatment of the infectious chronic refractory wounds.METHODS A total of 120 patients with chronic refractory wounds who were treated in the First Affiliated Hospital of Nanjing Medical University from Jul 2021 to Mar 2023 were recruited as the research subjects and randomly di-vided into the study group with 60 cases and the control group with 60 cases.The study group was treated with rhEGF combined with bFGF,while the control group was only treated with rhEGF.The inflammatory indexes,pain score,bacterial culture of wound secretions,growing status of wound granulation tissues and wound healing time were observed and compared between the two groups before and after the treatment.RESULTS There was no significant difference in the baseline data between the two groups of patients.There were no significant differences in the inflammatory indexes between the two groups before the treatment;the inflammatory indexes of the study group were lower than those of the control group after the treatment for 3 days(P<0.05).The pain scores of the study group were lower than those of the control group after the treatment for 3,7,and 14 days(P<0.05).There was significant difference in the result of bacterial culture for wound secretions between the two groups after the treatment for 7 and 14 days(P<0.05);the positive rate of bacterial culture of the study group was lower than that of the control group(P<0.05).The score of the study group was lower,there was between-group difference in the growing status of wound granulation tissues after the treatment for 7 and 14 days(P<0.05);there was no sig-nificant difference in the first 3 days.The wound healing time of the study group was shorter than that of the con-trol group(P<0.05).CONCLUSION rhEGF combined with bFGF may facilitate the remission of wound pain and inflammatory response,remarkably reduce the incidence of bacterial infection,and a

关 键 词：重组人表皮生长因子 碱性成纤维细胞生长因子 感染 慢性难愈性创面 临床疗效 

分 类 号：R473.6[医药卫生—护理学]