功能化GNPs在流行病快速检测和实体医疗中的应用  

Application of Functionalized GNPs in Rapid Epidemic Detectionand Physical Medicine

作　　者：陈少忠 王冬梅[1] CHEN Shaozhong;WANG Dongmei(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China)

机构地区：[1]福建师范大学生命科学学院,福州350117

出　　处：《中国细胞生物学学报》2024年第2期319-326,共8页Chinese Journal of Cell Biology

摘　　要：金纳米粒子(gold nanoparticles, GNPs)与不同分子偶联,不仅可优化其存储条件,还可起放大信号的功能。GNPs是种理想的偶联体,其生物相容性、低毒性、稳定性和表面功能化等特性使其应用具有极强的可塑性。功能化的GNPs为构建体外诊断产品提供了载具基础,在流行病肆虐前期,成熟完善的体外检测方法可提供快速实用和操作便捷的医疗检测。该文就功能化GNPs检测在流行病及医疗诊断中的应用进展进行综述,以期为体外检测和可视化检测等提供借鉴。GNPs(gold nanoparticles)coupled with different molecules can not only optimize their storage conditions,but also play a role in amplifying signals.GNPs are excellent conjugates with a very flexible applicability due to their biocompatibility,low toxicity,stability and surface functionalization.The functionalized GNPs provide a vehicle basis for the construction of in vitro diagnostic products.A sophisticated and flawless in vitro diagnostic can offer a quick,useful,and easy medical detection system in the early stages of the pandemic.In order to serve a reference for both visual and in vitro detection,this article examines the development of functional GNPs detection in epidemiology and medical diagnosis.

关 键 词：功能化GNPs 体外诊断产品 比色型检测 流行病 

分 类 号：O657[理学—分析化学] R313[理学—化学]