四维斑点追踪评价复方丹参滴丸对冠状动脉左前降支病变患者疗效的临床研究  

Clinical study on the effect of compound Danshen dropping pills on patients with left anterior descending coronary artery disease by four-dimensional spot tracking

作　　者：林秀梅 张娜[2] 朱雯 齐永涛 马桂凤[1] LIN Xiumei;ZHANG Na;ZHU Wen;QI Yongtao;MA Guifeng(Department of Ultrasound,the Affiliated Hospital of Weifang Medical University,Weifang 261031,China;Department of Gynecology,the Affiliated Hospital of Weifang Medical University)

机构地区：[1]潍坊医学院附属医院超声科,山东潍坊261031 [2]潍坊医学院附属医院妇一科

出　　处：《潍坊医学院学报》2024年第1期61-63,共3页Acta Academiae Medicinae Weifang

基　　金：潍坊市卫生健康委员会中医药科研立项项目(项目编号:WFZYY2022-4-027)。

摘　　要：目的 探究四维斑点追踪成像技术评估复方丹参滴丸对急性冠状动脉左前降支病变所致心肌梗死的临床疗效。方法 选取急性冠状动脉粥样硬化性心脏病择期手术患者66例为研究对象,随机分为对照组和观察组,每组33例。两组均接受经皮冠状动脉介入术(PCI)治疗,对照组给予阿司匹林肠溶片口服,观察组在对照组基础上口服复方丹参滴丸,连续治疗4周。比较两组左室相关心功能参数。结果 治疗前与治疗后相比,治疗后两组患者LVEF、LVIDs、LVIDd、FS、GLS-Avg、GLS-A2C以及观察组的GLS-LAX、GLS-A4C均比治疗前有明显改善(P<0.05);观察组与对照组相比,观察组LVEF、LVIDd、LVIDs、FS、GLS-Avg、GLS-LAX、GLS-A4C治疗前后的差值均大于对照组(P<0.05),说明观察组疗效更佳。结论 复方丹参滴丸应用于择期手术冠心病心肌缺血患者临床效果显著,能提高阿司匹林对急性心肌梗死的疗效,可有效改善患者症状,降低心肌缺血风险。Objective To evaluate the clinical effect of compound Danshen dropping pills on acute myocardial infarction caused by left anterior descending branch of coronary artery by using four-dimensional dot tracking imaging.Methods Sixty-six patients with coronary heart disease were selected and divided into control group and observation group by random number table method,33 patients in each group.Percutaneous coronary intervention was performed in both groups,and the control group was given aspirin enteric-coated tablets with the initial dose of 300mg and the continuous dose of 100mg per day,once per day.Observation group was additionally given compound Danshen dropping pill,10 capsules/time,3 times/day.The two groups were treated continuously for 4 weeks.Conventional echocardiography and 4D-STI were performed respectively in the two groups to measure left ventricular related cardiac function parameters,and the measured parameters were compared between the two groups.Results LVEF,left ventricular systolic diameter,left ventricular diastolic diameter,left ventricular short axis shortening rate(FS),GLS-Avg,GLS-A2C were statistically significant in control group and observation group before and after treatment(P<0.05).The differences of LVEF,LVIDd,LVIDs,SV,FS,GLS-LAX and GLS-A4C before and after treatment in the observation group were statistically significant compared with the control group(P<0.05).GLS-Avg and GLS-A4C in the observation group were significantly different from those in the control group after treatment(P<0.05).Conclusion The clinical effect of compound Danshen dripping pills on patients with coronary heart disease and myocardial ischemia during elective surgery is significant,which can improve the efficacy of aspirin on acute myocardial infarction,effectively improve the symptoms of patients and reduce the risk of myocardial ischemia.

关 键 词：复方丹参滴丸 斑点追踪成像技术 前壁心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]