血府逐瘀汤对狼疮性肾炎患者胸腺肽β4及Ea-RFC的影响  

Effects of Xuefu Zhuyu decoction on thymosinβ4 and Ea⁃RFC in patients with lupus nephritis

作　　者：徐娜[1] 韩梅[2] 封锦慧 孙垚 任占芬[3] 贾军利[4] XU Na;HAN Mei;FENG Jinhui;SUN Yao;REN Zhanfen;JIA Junli(Department of Pharmacy,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075100;Operating Room,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075100;Rheumatology and Immunology Department,the First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075100;Department of Nephrology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,China,075100)

机构地区：[1]河北北方学院附属第二医院药剂科,河北张家口075100 [2]河北北方学院附属第二医院手术室,河北张家口075100 [3]河北北方学院附属第一医院风湿免疫科,河北张家口075100 [4]河北北方学院附属第二医院肾内科,河北张家口075100

出　　处：《分子诊断与治疗杂志》2024年第3期403-406,411,共5页Journal of Molecular Diagnostics and Therapy

基　　金：张家口市重点研发计划项目(2121133D)。

摘　　要：目的探讨血府逐瘀汤辅助治疗狼疮性肾炎(LN)的效果及对患者胸腺肽β4及Ea花环细胞(Ea-RFC)形成率的影响。方法选取河北北方学院附属第二医院2020年1月至2021年6月收治的60例狼疮性肾炎患者,按随机数字表法分为观察组(行血府逐瘀汤联合泼尼松与环磷酰胺治疗)30例与对照组(行泼尼松与环磷酰胺治疗)30例,治疗18个月。观察组治疗后临床效果、中医症状、胸腺肽β4表达、Ea-RFC形成率、肾功能及不良反应。结果观察组治疗总有效率为96.67%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组纳少腹胀、腰膝酸软、面色不华、口黏口苦等中医症状积分低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组红细胞沉降率、血清肌酐及胸腺肽β4表达低于对照组,Ea-RFC形成率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论血府逐瘀汤辅助治疗LN患者疗效确切,能减少患者体内胸腺肽β4表达,提高Ea-RFC,改善肾功能,安全性较高。Objective To investigate the impact of Xuefu Zhuyu decoction on thymosinβ4 and erythrocyte-antibody rosette-forming cell(Ea-RFC)formation rate in the treatment of patients with lupus ne-phritis.Methods A total of 60 patients with lupus nephritis admitted to the Second Affiliated Hospital of He-bei North University from January 2020 to June 2021 were selected and divided into two groups:the observa-tion group(Xuefu Zhuyu decoction combined with prednisone and cyclophosphamide,30 cases)and the con-trol group(prednisone and cyclophosphamide,30 cases)based on the random number table method.Both groups underwent an 18-month treatment period.After treatment,the clinical outcomes,Traditional Chinese Medicine(TCM)symptoms,thymosinβ4 expression,Ea-RFC formation rate,renal function and adverse re-actions were monitored and compared between the two groups.Results After treatment,the total effective rate of treatment in the observation group was 96.67%,which was higher than the 80.00%in the control group(P<0.05).Additionally,the scores of TCM symptoms such as poor appetite,abdominal distension,soreness and weakness of waist and knees,pale complexion and sticky and bitter mouth in the observation group were lower than those in the control group(P<0.05)after treatment.Furthermore,after treatment,the erythrocyte sedimentation rate and expressions of serum creatinine and thymosinβ4 in the observation group were lower,while the Ea-RFC formation rate was higher compared to the control group(P<0.05).It is important to note that after treatment,there were no statistically significant differences in the incidence rates of adverse reactions between the observation group and the control group(P>0.05).Conclusion Xuefu Zhuyu decoction has been shown have a significant efficacy in treating patients with LN.It can reduce the expression of thymosinβ4 in vivo,increase Ea-RFC and improve renal function,all while maintaining a high level of safety.

关 键 词：血府逐瘀汤 狼疮性肾炎 免疫功能 胸腺肽β4 Ea花环细胞 

分 类 号：R259[医药卫生—中西医结合]