糖尿病视网膜病变患者SDF-1、HO-1及MDA水平变化及与IL-6、TNF-α、CRP的相关性  

Changes of SDF⁃1,HO⁃1 and MDA levels in patients with diabetic retinopathy and their correlation with IL⁃6,TNF⁃αand CRP

作　　者：赵玉杰[1] 王敏[1] 刘钰凤[1] 刘学晶[1] 钟胜楠 李莹[1] ZHAO Yujie;WANG Min;LIU Yufeng;LIU Xuejing;ZHONG Shengnan;LI Ying(Department of Ophthalmology,the First Medical Center of the General Hospital of the People's Liberation Army,Beijing,China,100853)

机构地区：[1]解放军总医院第一医学中心眼科,北京100853

出　　处：《分子诊断与治疗杂志》2024年第3期539-542,552,共5页Journal of Molecular Diagnostics and Therapy

基　　金：北京市科技计划课题(Z221100007422121)。

摘　　要：目的 分析糖尿病视网膜病变(DR)患者基质细胞衍生因子(SDF-1)、血红素加氧酶-1(HO-1)及丙二醛(MDA)水平变化及与白介素-6(IL-6)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)的相关性。方法 选取2020年5月至2023年1月解放军总医院收治的131例DR患者为DR组,另选取同期在本院住院的2型糖尿病患者100例为非DR组。比较两组SDF-1、HO-1、MDA水平;比较两组IL-6、TNF-α、CRP水平;比较不同分期DR患者SDF-1、HO-1、MDA水平;采用Logistic回归分析影响DR发生的相关因素,分析DR组患者SDF-1、HO-1、MDA水平与IL-6、TNF-α、CRP的相关性。结果 DR组SDF-1、HO-1水平比非DR组低,MDA水平比非DR组高,差异有统计学意义(P<0.05);DR组IL-6、TNF-α、CRP水平均比非DR组高,差异有统计学意义(P<0.05);SDF-1、HO-1水平:Ⅰ~Ⅱ期>Ⅲ~Ⅳ期>Ⅴ~Ⅵ期,MDA水平:Ⅰ~Ⅱ期<Ⅲ~Ⅳ期<Ⅴ~Ⅵ期,差异有统计学意义(P<0.05);经Logistic多因素分析显示,性别为女、BMI≥24 km/m2、合并患有高血压、高血脂、IL-6>1.17 mg/mL、TNF-α>30 ng/L、CRP>10 ng/mL、SDF-1>2 ng/mL、HO-1<125 ng/mL、MDA>4.06μmol/mL均是影响DR发生的独立危险因素(P<0.05);血清炎性因子IL-6、TNF-α、CRP与SDF-1、HO-1呈负相关,与MDA呈正相关,且均为中度相关(P<0.05)。结论 SDF-1、HO-1、MDA、IL-6、CRP、TNF-α水平与DR的发生、发展有一定关系,通过检测上述指标水平可为进一步探讨DR的发病机制和治疗方法提供新的思路。Objective To analyze the changes of stromal cell derived factor(SDF-1),heme oxy-genase-1(HO-1)and malondialdehyde(MDA)levels in patients with diabetic retinopathy(DR)and their cor-relation with interleukin-6(IL-6),tumor necrosis factor(TNF-α)and C-reactive protein(CRP).Methods A total of 131 patients with DR were admitted to our hospital from May 2020 to January 2023 and were select-ed as the DR Group.Another 100 patients with type 2 diabetes admitted to our hospital during the same period were selected as the non-DR group.The levels of SDF-1,HO-1 and MDA were compared between the two groups,as well as the levels of IL-6,TNF-αand CRP.Furthermore,the levels of SDF-1,HO-1 and MDA in patients with different stages of DR were compared.Logistic regression was used to analyze the related factors affecting the occurrence of DR,and the correlation of SDF-1,HO-1 and MDA levels with IL-6,TNF-αand CRP in the DR Group was analyzed.Results The levels of SDF-1 and HO-1 in the DR group were lower than those in the non-DR group,and MDA levels in the DR group were higher than those in the non-DR group(P<0.05).The levels of IL-6,TNF-αand CRP in the DR group were higher than those in the non-DR group(P<0.05).SDF-1 and HO-1 levels were observed to be highest in the I-II period,followed by theⅢ-Ⅳperiod,and lowest in theⅤ-Ⅵperiod.Conversely,MDA levels were highest in theⅤ-Ⅵperiod,followed by theⅢ-Ⅳperiod,and lowest in theⅠ-Ⅱperiod.These difference was statistically significant(P<0.05).Logistic multivariate analysis showed that female gender,BMI≥24 km/m2,combined hypertension,hyperlipidemia,IL-6>1.17 mg/mL,TNF-α>30 ng/L,CRP>10 ng/mL,SDF-1>2 ng/mL,HO-1<125 ng/mL,and MDA>4.06μmol/mL were all independent risk factors affecting the occurrence of DR(P<0.05).Furthermore,serum inflammatory factors IL-6,TNF-αand CRP showed a negative correlation with SDF-1 and HO-1,but a posi-tive correlation with MDA(P<0.05).Conclusion The levels of SDF-1,HO-1,MDA,IL-6,CRP,and TNF-αhave a certain relationship with the occurrence

关 键 词：糖尿病视网膜病变 SDF-1 HO-1 MDA IL-6 CRP TNF-α 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]