miRNA-223、miRNA-21及miRNA-27a与冠心病冠脉病变的关系  

Relationship between miRNA⁃223,miRNA⁃21 and miRNA⁃27a and coronary artery lesions in coronary heart disease

作　　者：马永[1] 高辉[2] 王明岗[2] 赵斌[3] MA Yong;GAO Hui;WANG Minggang;ZHAO Bin(Department of General Medicine,Shangqiu,Henan,China,476000;Department of Cardiology,Shangqiu,Henan,China,476000;Department of Laboratory Medicine,Shangqiu First People's Hospital,Shangqiu,Henan,China,476000)

机构地区：[1]商丘市第一人民医院全科医学科,河南商丘476000 [2]商丘市第一人民医院心内科,河南商丘476000 [3]商丘市第一人民医院检验科,河南商丘476000

出　　处：《分子诊断与治疗杂志》2024年第2期361-364,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(LHGJ20210988)。

摘　　要：目的 探讨miRNA-223、miRNA-21及miRNA-27a与冠心病冠脉病变的关系。方法 选取2021年1月至2022年12月商丘市第一人民医院收治的CHD患者86例为观察组,选取70名同期院内健康体检者作为对照组。对比两组血清miRNA-223、miRNA-21、miRNA-27a水平;分析影响CHD冠脉病变的单因素,采用Logistic回归分析影响CHD冠脉病变的单因素、多因素;对比不同CHD冠脉病变类型的血清miRNA-223、miRNA-21、miRNA-27a水平;对比不同CHD冠脉病变支数的血清miRNA-223、miRNA-21、miRNA-27a水平。结果 观察组miRNA-223、miRNA-21、miRNA-27a表达水平比对照组高,差异有统计学意义(P<0.05);Logistic多因素分析显示,患有高血压、糖尿病以及miRNA-223>1.5、miRNA-21>6.0、miRNA-27a>5.5均是影响CHD冠脉病变的独立危险因素(P<0.05);miRNA-223、miRNA-21、miRNA-27a表达水平:急性心肌梗死>不稳定型心绞痛>稳定型心绞痛,差异有统计学意义(P<0.05);miRNA-223、miRNA-21、miRNA-27a表达水平:三支>双支>单支,差异有统计学意义(P<0.05)。结论 不同冠脉病变CHD患者miRNA-223、miRNA-21、miRNA-27a表达水平不同,提示以上指标对判断CHD患者冠脉病变类型具有一定的临床价值。Objective To explore the relationship between miRNA-223,miRNA-21 and miRNA-27a and coronary artery disease and coronary artery disease.Methods A total of 86 CHD patients were admitted to our hospital from January 2021 to December 2022 and were selected as the observation group.Additionally,70 healthy individuals undergoing physical examination in the hospital during the same period were selected as the control group.The serum levels of miRNA-223,miRNA-21 and miRNA-27a were compared between the two groups.Logistic regression was used to analyze the single and multiple factors affecting CHD coronary ar-tery disease.The serum levels of miRNA-223,miRNA-21 and miRNA-27a were compared among different types of CHD coronary artery disease.The levels of serum miRNA-223,miRNA-21,and miRNA-27a were com-pared across different counts of CHD coronary artery disease.Results The expression levels of miRNA-223,miRNA-21,and miRNA-27a were higher than those in the control group,and the difference was statistically significant(P<0.05).Logistic multivariate analysis showed that hypertension,diabetes and miRNA-223>1.5,miRNA-21>6.0 and miRNA-27a>5.5 were independent risk factors for coronary disease in CHD(P<0.05).The expression levels of miRNA-223,miRNA-21,and miRNA-27a were as follows:acute myocardial infarction>unstable angina>stable angina,the difference was statistically significant(P<0.05).The expression levels of miRNA-223,miRNA-21,and miRNA-27a were as follows:three>two>single mirNA-27A,the difference was statistically significant(P<0.05).Conclusion The expression levels of miRNA-223,miRNA-21,and miRNA-27a vary in CHD patients with different coronary artery lesions.This suggests that these indicators have clinical value in determining the type of coronary artery lesions in CHD patients.

关 键 词：miRNA-223 MIRNA-21 miRNA-27a 冠心病 冠脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]