盐酸特拉唑嗪联合非那雄胺片治疗对良性前列腺增生患者临床疗效、控尿功能及炎性因子的影响  

Effects of terazosin hydrochloride combined with finasteride tablets on clinical efficacy,urinary control function and inflammatory factors in patients with benign prostatic hyperplasia

作　　者：杨淑媛 王印 马兰 余美霖 廖先花 YANG Shuyuan;WANG Yin;MA Lan;YU Meilin;LIAO Xianhua(Department of Pharmacy,Chengdu Jinsha Hospital,Chengdu,Sichuan,China,610000;Department of Pharmacy,Chengdu Women and Children Hospital,Chengdu,Sichuan,China,610000;Department of Pharmacy,Shanghai Gaobo Cancer Hospital,Shanghai,China,200120)

机构地区：[1]成都金沙医院药剂科,四川成都610000 [2]成都市妇女儿童医院药剂科,四川成都610000 [3]上海高博肿瘤医院药剂科,上海200120

出　　处：《分子诊断与治疗杂志》2024年第2期370-373,378,共5页Journal of Molecular Diagnostics and Therapy

基　　金：四川省科技计划项目(2022YJ0217)。

摘　　要：目的 分析盐酸特拉唑嗪联合非那雄胺片治疗对良性前列腺增生患者(BPH)临床疗效、控尿功能及炎性因子的影响。方法 选取成都金沙医院2019年7月至2023年1月收治的良性前列腺增生患者129例,根据治疗方式分为对照组63例(非那雄胺片)、观察组(盐酸特拉唑嗪+非那雄胺片)66例。比较两组总疗效率、前列腺体积、IPSS评分、控尿功能、炎性因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、前列腺特异抗原(PSA)、总前列腺特异抗原(tPSA)及不良反应。结果 观察组总疗效率、控尿率高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组前列腺体积、IPSS评分、IL-6、TNF-α、PSA及tPSA水平均低于对照组,差异均有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论 使用盐酸特拉唑嗪联合非那雄胺片治疗BPH患者总疗效率高,可显著改善患者控尿功能,调节炎性因子,降低PSA及tPSA水平,且用药安全性可靠。Objective To analyze the effects of terazosin hydrochloride combined with finasteride tablets on clinical efficacy,urinary control function and inflammatory factors in patients with benign prostatic hyperplasia(BPH).Methods A total of 129 patients with benign prostatic hyperplasia were admitted to Chengdu Jinsha Hospital from July 2019 to January 2023.They were divided into two groups based on their treatment methods:a control group of 63 cases(finasteride tablets)and an observation group of 66 cases(tera-zosin hydrochloride+finasteride tablets).The overall efficacy rate,prostate volume,IPSS score,urinary con-trol function,inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],prostate-specif-ic antigen(PSA),total prostate-specific antigen(tPSA)and adverse reactions were compared between the two groups.Results The total curative effect rate and urinary control rate of the observation group were high-er than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the prostate volume,IPSS score,IL-6,TNF-α,PSA and tPSA levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no sig-nificant difference in adverse reactions between the two groups(P>0.05).Conclusion Terazosin hydrochlo-ride combined with finasteride tablets in the treatment of BPH patients has shown a high overall efficacy rate.This treatment can significantly improve urinary control function,regulate inflammatory factors,and reduce leveld of PSA and tPSA.The drug is considered safe and reliable.

关 键 词：盐酸特拉唑嗪 非那雄胺片 良性前列腺增生 炎性因子 

分 类 号：R697.3[医药卫生—泌尿科学]