肾移植术后发生糖尿病的影响因素  

Influencing factors of diabetes after kidney transplantation

作　　者：陆婷 王雪静[2] 谭若芸 彭宇竹[1] LU Ting;WANG Xuejing;TAN Ruoyun;PENG Yuzhu(School of Public Health,Nanjing Medical University,Nanjing 211112,China;Department of Urology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学公共卫生学院,南京211112 [2]南京医科大学第一附属医院泌尿外科

出　　处：《肾脏病与透析肾移植杂志》2024年第1期36-40,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：目的:探讨肾移植术后1年糖尿病的发生率及影响因素。方法:回顾性分析2016年1月至2020年12月南京医科大学第一附属医院肾移植中心347例术前无糖尿病的肾移植受者的临床资料,统计移植术后糖尿病(PTDM)发生率,采用单因素和多因素Logistic回归分析方法分析PTDM发生的影响因素。结果:347例术前无糖尿病的肾移植受者中,术后1年发生PTDM 79例(22.8%)。单因素分析显示,受者移植年龄(OR=1.034)、活体供肾(OR=0.178)、术前空腹血糖(OR=1.412)、术后服用环孢素A(OR=0.377)、他克莫司(OR=2.244)是术后1年发生PTDM的影响因素(P<0.05),多因素分析显示,移植年龄和术前空腹血糖是术后1年发生PTDM发生的独立危险因素(P<0.05)。结论:术后1年发生PTDM与受者移植年龄、活体供肾、术前空腹血糖、服用环孢素A和他克莫司密切相关。Objective:To investigate the incidence and influencing factors of diabetes mellitus(PTDM)one year after renal transplantation.Methodology:Retrospective analysis was made on the clinical data of 347 renal transplant recipients without diabetes before operation in the Renal Transplantation Center of the First Affiliated Hospital of Nanjing Medical University from January 2016 to December 2020.Calculate the incidence of PTDM and analyze the influencing factors of PTDM using univariate and multivariate logistic regression analysis methods.Results:Among 347 renal transplant recipients without diabetes before operation,79 cases had PTDM one year after operation(22.8%).Univariate analysis showed that transplant age(OR=1.034),living donor kidney(OR=0.178),preoperative fasting blood glucose(OR=1.412),postoperative cyclosporine(OR=0.377),and tacrolimus(OR=2.244)were the influencing factors for PTDM occurrence one year after kidney transplantation(P<0.05).Multivariate analysis showed that transplant age and preoperative fasting blood glucose were independent risk factors for PTDM occurrence one year after kidney transplantation(P<0.05).Conclusion:The occurrence of PTDM one year after kidney transplantation is closely related to the recipient's transplant age,living donor kidney,preoperative fasting blood glucose,and the use of cyclosporine and tacrolimus.

关 键 词：肾移植 移植后糖尿病 影响因素 

分 类 号：R699.2[医药卫生—泌尿科学] R587.1[医药卫生—外科学]