腹膜转运功能的分子遗传学机制  

Molecular genetic mechanism of peritoneal transport function

作　　者：姚佳妮(综述) 沈茜(审校) YAO Jiani;SHEN Qian(Department of Nephrology,Childrens Hospital of Fudan University,National Center for Childrens Health,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心复旦大学附属儿科医院肾脏科,上海201102

出　　处：《肾脏病与透析肾移植杂志》2024年第1期82-86,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：腹膜透析是终末期肾病的治疗方式之一,其利用腹膜的半透膜特性,通过腹腔透析液不断地更换,清除体内代谢产物及纠正水、电解质平衡紊乱。近来研究表明,多种分子的基因多态性均与腹膜功能相关,从而影响透析患者的预后,其对透析患者的处方及预后具有提示性意义。本文旨在阐述目前腹膜转运功能相关的分子遗传学机制的研究进展。Peritoneal dialysis(PD)is one of the treatment methods for end⁃stage kidney disease.It uses the semipermeable membrane characteristics of the peritoneum to remove metabolites in the body and correct the imbalance of water and electrolyte through continuous replacement of peritoneal dialysate.Recent studies have shown that polymorphisms of multiple molecules are correlated with peritoneal function,thereby affecting the prognosis of patients,which has suggestive significance for the prescription and prognosis of dialysis patients.The purpose of this article is to review the current research progress of molecular genetic mechanism related to peritoneal transport function.

关 键 词：腹膜透析 腹膜功能 分子多态性 

分 类 号：R692.5[医药卫生—泌尿科学]