斑秃的氧化应激和潜在抗氧化疗法  

Oxidative Stress and Potential Antioxidant Therapies in Alopecia Areata

作　　者：孙超 宋冰 张景瑜 柴宝 詹淑霞[1] 陈宏翔 SUN Chao;SONG Bing;ZHANG Jingyu;CHAI Bao;ZHAN Shuxia;CHEN Hongxiang(Department of Dermatology,Shenzhen Qianhai Shekou Free Trade Zone Hospital,Shenzhen 518000,China;Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518000,China;Department of Dermatology,The Sixth Affiliated Hospital of Shenzhen University Medical School,Shenzhen 518052,China;Department of Dermatology,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 518052,China;Department of Dermatology,Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]深圳市前海蛇口自贸区医院皮肤科(医学美容科),广东深圳518000 [2]中国科学院深圳先进技术研究院,生物医学与健康工程研究所,广东深圳518000 [3]深圳大学附属第六医院,广东深圳518052 [4]华中科技大学协和深圳医院皮肤科,广东深圳518052 [5]华中科技大学同济医学院附属协和医院皮肤科,湖北武汉430022

出　　处：《皮肤科学通报》2024年第1期83-87,共5页Dermatology Bulletin

基　　金：深圳市南山区卫生健康系统科技计划项目(NS2022037,NSZD2023052,NSZD2023007);深圳市科技计划项目(JCYJ20230807115407016,JCYJ20210324112213036)。

摘　　要：斑秃(alopecia areata,AA)是一种以非瘢痕性脱发为特征的自身免疫性皮肤病。尽管毛囊(HF)免疫豁免(IP)失效被认为是斑秃主要的驱动因素,但AA的确切发病机制仍不清楚。其他因素,如遗传倾向、过敏、微生物群和心理压力等,在AA的发生和发展中也发挥着重要作用。氧化应激(oxidative stress,OS)是氧化和抗氧化防御系统之间的不平衡,在皮肤疾病中起着重要作用。本综述的目的是阐明OS在AA发病机制和诊断中的作用,并讨论相关生物标记物及潜在的抗氧化治疗方案。Alopecia areata(AA)is an autoimmune skin disorder characterized by non-scarring hair loss.Despite the immune privilege(IP)failure of hair follicles(HF)being considered a primary driving factor in AA,the exact pathogenic mechanism remains unclear.Other factors such as genetic predisposition,allergies,microbial flora,andpsychological stress also play significant roles in the occurrence and development of AA.Oxidative stress(OS),an imbalance between oxidation and antioxidant defense systems,plays a crucial role in skin diseases.The purpose of this review is to elucidate the role of OS in the pathogenesis and diagnosis of AA,discussing relevant biomarkers,and potential antioxidant therapeutic approaches.

关 键 词：斑秃 氧化应激 生物标志物 自噬 抗氧化 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]