卵巢子宫内膜异位囊肿患者血清APRIL与NDRG1的水平表达及其临床价值研究  

Expression of Serum APRIL and NDRG1 Levels in Patients with Ovarian Endometrioma and Their Clinical Value

作　　者：罗亮 许剑利[1] 程其军 阴莉[1] LUO Liang;XU Jianli;CHENG Qijun;YIN Li(Department of Obstetrics and Gynecology,Zigong First People’s Hospital,Sichuan Zigong 643000,China)

机构地区：[1]自贡市第一人民医院妇产科,四川自贡643000

出　　处：《现代检验医学杂志》2024年第2期124-128,共5页Journal of Modern Laboratory Medicine

摘　　要：目的观察血清增殖诱导配体(a proliferation inducing ligand,APRIL),N-myc下游调节基因1(N-myc downstream regulated gene 1,NDRG1)水平变化,并分析其对卵巢子宫内膜异位囊肿(ovarian endometriomas,OEM)的诊断价值。方法选取2021年7月~2022年7月在自贡市第一人民医院就诊的132例OEM患者作为观察组,并进行定期随访,根据患者预后病情有无复发分为复发组(n=50)和未复发组(n=82)。同期在该院体检的健康者78例为对照组。采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测血清中APRIL和NDRG1水平;并对复发组和未复发组的一般资料进行比较;采用Logistic回归分析影响OEM预后的相关因素;用Pearson法分析OEM患者血清APRIL与NDRG1表达相关性;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析血清APRIL和NDRG1对OEM的诊断价值。结果与对照组相比,APRIL水平(35.28±6.81ng/ml vs 26.37±3.19ng/ml)和NDRG1水平(124.39±15.67μg/L vs 9.67±10.82μg/L)升高,差异具有统计学意义(t=10.864,17.278,均P<0.05)。与未复发组比较,复发组血清APRIL(40.38±7.88ng/ml vs 32.16±6.18ng/ml)和NDRG1(132.04±19.83μg/L vs 119.73±13.16μg/L)水平升高,差异具有统计学意义(t=6.668,4.287,均P<0.05)。Logistic回归分析显示,血清APRIL和NDRG1水平是影响OEM患者预后的危险因素(Waldχ^(2)=11.839,28.437,均P<0.001)。Pearson法分析结果显示,OEM患者血清APRIL水平与NDRG1水平呈正相关(r=0.439,P<0.001)。血清APRIL,NDRG1水平联合诊断OEM的曲线下面积(AUC)为0.849,灵敏度和特异度分别为73.95%,85.37%,优于APRIL和NDRG1单独预测(Z=2.644,2.094,P=0.008,0.036)。结论子宫内膜异位囊肿患者血清APRIL和NDRG1水平升高,二者联合对子宫内膜异位囊肿诊断具有较高的临床价值,且与子宫内膜异位囊肿患者的预后密切相关。Objective To observe the changes in serum a proliferation inducing ligand(a proliferation inducing ligand,APRIL)and N-myc downstream regulated gene 1(N-myc downstream regulated gene 1,NDRG1)levels,and analyze their diagnostic value for ovarian endometrioma(OEM).Methods From July 2021 to July 2022,132 patients with OEM who visited Zigong First People’s Hospital were regarded as the observation group,and regular follow-up was conducted.According to the prognosis of these patients,they were grouped into the recurrence group(n=50)and the non recurrence group(n=82).Meanwhile,78 healthy individuals who had their medical checkups at the hospital during the same period were the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum APRIL and NDRG1 levels,and the general data of the recurrent and non recurrent groups were compared.Logistic regression analysis was applied to analyze the relevant factors affecting the prognosis of OEM.Pearson analysis was applied to explore the correlation between serum APRIL and NDRG1 levels in patients with OEM.Receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum APRIL,NDRG1 levels and their combination for OEM.Results Compared with the control group,APRIL level(35.28±6.81ng/ml vs 26.37±3.19ng/ml)and NDRG1 level(124.39±15.67μg/L vs 9.67±10.82μg/L)in observation group were increased,and the differences were significant(t=10.864,17.278,all P<0.05).Compared with the non recurrence group,the serum levels of APRIL(40.38±7.88ng/ml vs 32.16±6.18ng/ml)and NDRG1(132.04±19.83μg/L vs 119.73±13.16μg/L)in the recurrence group were increased,and the differences were significant(t=6.668,4.287,all P<0.05).Logistic regression analysis showed that serum APRIL and NDRG1 levels were risk factors for the prognosis of patients with OEM(Waldχ^(2)=11.839,28.437,all P<0.001).Pearson method analysis results showed a positive correlation between serum APRIL level and NDRG1 level in patients with OEM(r=0.439,P<0.001).The area unde

关 键 词：卵巢子宫内膜异位囊肿 增殖诱导配体 N-myc下游调节基因1 

分 类 号：R711.71[医药卫生—妇产科学] R392.11[医药卫生—临床医学]