复发鼻息肉组织各类炎性细胞变化的独立因素分析  

The analysis of independent factors affecting tissue inflammatory cells changes in recurrent nasal polyps

作　　者：宋哲莹 王建伟[2,3,4] 罗祥煌 杨玉娟 张宇 宋西成[2,3,4] SONG Zheying;WANG Jianwei;LUO Xianghuang;YANG Yujuan;ZHANG Yu;SONG Xicheng(School of Clinical Medicine,Shandong Second Medical University,Weifang,Shandong,261000,China;Department of Otolaryngology Head and Neck Surgery,Yantai Yuhuangding Hospital,Qingdao University,Yantai,Shandong,264000,China;Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases,Yantai,Shandong,264000,China;Yantai Key Laboratory of Otorhinolaryngologic Diseases,Yantai,Shandong,264000,China)

机构地区：[1]山东第二医科大学临床医学院,山东潍坊261000 [2]青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科,山东烟台264000 [3]山东省耳鼻喉疾病临床医学研究中心,山东烟台264000 [4]烟台市耳鼻喉疾病重点实验室,山东烟台264000

出　　处：《中国耳鼻咽喉头颈外科》2024年第2期109-112,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金面上项目(82271146、82271147);山东省重点研发计划(重大科技创新工程)项目(2020CXGC011302、2022CXGC020506)。

摘　　要：目的探讨影响复发鼻息肉组织各类炎性细胞变化的独立影响因素。方法选择2007年12月~2021年12月原发鼻息肉与复发鼻息肉均在烟台毓璜顶医院耳鼻咽喉头颈外科行鼻内镜手术治疗的31例鼻息肉患者临床资料,进行逐步回归Logistic分析。结果相较于原发鼻息肉,复发鼻息肉各类组织浸润炎性细胞数量均发生变化,其中嗜中性粒细胞计数和百分比均显著升高(P<0.05)。Logistic分析发现吸烟是复发鼻息肉嗜酸性粒细胞增多的独立危险因素,年龄增大是促进嗜中性粒细胞降低的独立因素,合并变应性鼻炎和复发时间间隔分别是促进淋巴细胞降低和增多的独立因素。结论复发鼻息肉组织各类浸润细胞数量均较原发鼻息肉发生变化。吸烟是复发鼻息肉嗜酸性粒细胞增多的独立危险因素。OBJECTIVE To explore the independent factors affecting tissue inflammatory cells changes in recurrent nasal polyps.METHODS The clinical data of 31 patients with nasal polyps who underwent endoscopic surgery at the Department of Otolaryngology Head and Neck Surgery,Yantai Yuhuanding Hospital from December 2007 to December 2021 were selected and analyzed by stepwise regression logistic analysis.RESULTS The number of tissue inflammatory cells in recurrent nasal polyps changed compared with that in primary nasal polyps,and the number and percentage of neutrophils in recurrent polyps increased(P<0.05).Logistic analysis revealed that smoking was an independent risk factor for eosinophilia in recurrent nasal polyps,increasing age was an independent factor for lowering neutrophils,and the comorbid allergic rhinitis and the time interval of recurrence were independent factors for lowering and increasing lymphocytes,respectively.CONCLUSION The number of tissue-infiltrating cells is altered in recurrent polyps compared with primary polyps.Smoking is an independent risk factor for eosinophilia in recurrent polyps.

关 键 词：鼻息肉 中性白细胞 嗜酸细胞 淋巴细胞 危险因素 独立因素 

分 类 号：R765.9[医药卫生—耳鼻咽喉科]