Cronkhite-Canada综合征合并无症状新型冠状病毒感染一例  

Cronkhite⁃Canada Syndrome Combined with Asymptomatic Novel Coronavirus Infection:A Case Report

作　　者：张宁 杨晨皓 周良瑞 孙晓红 刘晓红 康琳 李骥[4] 李海龙 ZHANG Ning;YANG Chenhao;ZHOU Liangrui;SUN Xiaohong;LIU Xiaohong;KANG Lin;LI Ji;LI Hailong(Department of Geriatrics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Internal Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Clinical Nutrition,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院老年医学科,北京100730 [2]中国医学科学院北京协和医院内科学系,北京100730 [3]中国医学科学院北京协和医院病理科,北京100730 [4]中国医学科学院北京协和医院消化内科,北京100730 [5]中国医学科学院北京协和医院临床营养科,北京100730

出　　处：《协和医学杂志》2024年第2期406-412,共7页Medical Journal of Peking Union Medical College Hospital

基　　金：中央高水平医院临床科研专项(2022⁃PUMCH⁃B⁃132)。

摘　　要：本文报道Cronkhite⁃Canada综合征合并无症状新型冠状病毒感染1例。该患者临床表现为食欲减退,毛发及指甲脱落,皮肤色素沉着。内镜检查见胃、十二指肠及结肠黏膜呈弥漫性、大小不一、密集分布的息肉样改变。病程中检出新型冠状病毒核酸阳性。经中等剂量泼尼松治疗后,患者毛发恢复生长,皮肤色素沉着减退。本文总结该患者的诊疗经过并结合文献复习,以期提升临床医生对该病的认知。This article presents a case study of a patient who had Cronkhite⁃Canada syndrome in combina⁃tion with an asymptomatic novel coronavirus infection.The patient exhibited clinical symptoms of loss of appetite,hair and nail loss,and skin pigmentation.Digestive endoscopy revealed widespread and varying⁃sized polypoid changes in the mucosa of the stomach,duodenum,and colon.During the course of the illness,the patient tested positive for novel coronavirus nucleic acid.Treatment with moderate doses of prednisone resulted in the patient’s hair regrowth and decreased skin hypopigmentation.The article provides a summary of the patient’s diagnosis and treatment and a review of relevant literature,with the aim of enhancing clinicians’understanding of the disease.

关 键 词：Cronkhite⁃Canada综合征 新型冠状病毒感染 治疗 

分 类 号：R751[医药卫生—皮肤病学与性病学] R57[医药卫生—临床医学]