幼年接种天花疫苗对成年猴痘病例临床特征的影响分析  

Effect of childhood smallpox vaccination on clinical characteristics of adult mpox cases

作　　者：李丹 任振勇[1] 窦相峰[1] 孙玉兰[1] 金昊源 李仁清[1] 李夫 张代涛[1] Li Dan;Ren Zhenyong;Dou Xiangfeng;Sun Yulan;Jin Haoyuan;Li Renqing;Li Fu;Zhang Daitao(Institute for Infectious Disease and Endemic Disease Control,Beijing Municipal Center for Disease Prevention and Control,Beijing Research Center for Preventive Medicine,Beijing 100013,China)

机构地区：[1]北京市疾病预防控制中心传染病地方病控制所,100013

出　　处：《国际病毒学杂志》2024年第1期75-78,共4页International Journal of Virology

摘　　要：目的通过对比分析幼年是否接种天花疫苗的猴痘病例的临床特征、流行病学特征及实验室检测结果,探索猴痘确诊病例中幼年是否接种天花疫苗是否会对发病、临床特征及实验室检测产生影响.方法将北京市2023年5月至2023年8月猴痘确诊病例中接种过天花疫苗的病例纳入接种疫苗组,未接种天花或猴痘疫苗的人群纳入未接种疫苗组.通过流调、电子病历查询和电话随访的方式收集数据,对比分析两组人群的人口学资料、发病就诊情况、临床特征、流行病学信息和实验室检测结果.结果本研究共纳入90例,其中接种疫苗组(接种组)10例,未接种疫苗组(未接种组)80例,均为男性.接种组病例平均年龄(47.50±5.06)岁,未接种组病例平均年龄(31.68±5.34)岁;接种组中有9名为男男性行为(MSM)人群,6名HIV感染者;未接种组有78例MSM人群,43名HIV感染者.是否就诊、是否发病、发病与诊断时间差和21 d是否有性行为等指标中,接种组和未接种组差异均无统计学意义(P>0.05);发热、皮疹、皮疹发生部位、淋巴结肿大等临床特征在接种组和未接种组差异均无统计学意义(P>0.05);实验室指标中,咽拭子是否阳性在接种组和未接种组的差异有统计学意义(P<0.05);皮疹涂抹/痂皮是否阳性及Ct值分布在接种组和未接种组差异均无统计学意义(P>0.05).结论幼年接种天花疫苗,仍可以罹患猴痘.在猴痘确诊病例中接种天花疫苗的人群与未接种天花的人群相比,临床特征和流行病学特征无显著差异.但在后续猴痘疫苗的研发和接种过程中也不可忽视曾接种过天花疫苗的人群.Objective To compare the clinical features,epidemiological characteristics and laboratory testing results of mpox cases with or without smallpox vaccination in childhood,so as to explore the effect of smallpox vaccination in childhood on disease onset,clinical characteristics and laboratory testing results among confirmed mpox cases.Methods The confirmed cases of mpox who received smallpox vaccination in childhood in Beijing from May 2023 to August 2023 were enrolled in the vaccination group,and the cases in the same period who had no smallpox or mpox vaccination were enrolled in the unvaccinated group.The data were collected through epidemiological investigations,electronic medical record queries,and telephone follow-ups.The demographic information,disease onset and hospital visit,clinical features,epidemiological information and laboratory between the two groups were compared and analyzed.Results A total of 90 cases were included in this study,including 10 cases in the vaccinated group and 80 cases in the unvaccinated group.All cases were males.The mean age of patients in the vaccinated group was 47.50±5.06 years old,and that in the unvaccinated group was 31.68±5.34 years old.In the vaccination group,there were 9 men who have sex with men(MSM)and 6 were HIV-infected.In the unvaccinated group,there were 78 MSM and 43 HIV-infected patients.The differences in seeking for medical treatment,onset of disease,the time interval between onset and diagnosis,and having sexual behavior within the past 21 days between the vaccinated group and the unvaccinated group were not statistically significant(P>0.05).The differences in clinical features,including fever,rash,site of rash and lymph node enlargement between the vaccinated group and the unvaccinated group were not statistically significant(P>0.05).Among laboratory testing criteria,the difference in the positive of the throat swab between the vaccinated group and the unvaccinated group were statistically significant(P<0.05).The differences in positive of the rash smear/

关 键 词：猴痘 天花疫苗 临床特征 

分 类 号：R511[医药卫生—内科学]