蝮蛇咬伤中医治疗优化方案的疗效评价  

Evaluation of the Therapeutic Effect of Optimized Traditional Chinese Medicine Treatment for Agkistrodon Halys Bite

作　　者：张允申[1] 方勇 陈海东[1] 龚旭初 ZHANG Yunshen;FANG Yong;CHEN Haidong;GONG Xuchu(Nantong Hospital Affiliated to Nanjing University of Chinese Medicine,Nantong 226000,China)

机构地区：[1]南京中医药大学南通附属医院,江苏南通226000

出　　处：《云南中医药大学学报》2024年第1期33-39,共7页Journal of Yunnan University of Chinese Medicine

基　　金：第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号);国家中医药管理局重点专科项目(国中医药办医政函[2019]210号);江苏省中医药重点学科(中医外科)项目(苏中医科教[2018]1号);第二批江苏省名老中医药专家传承工作室建设项目(苏中医科教[2016]6号);南通市"十四五"科教强卫工程青年医学重点人才项目(通卫科教[2021]15号);中国民族医药学会科研项目(2022Z1051-350101);南通市市级科技计划项目(MAZ19228)。

摘　　要：目的评价中医优化方案治疗蝮蛇咬伤的临床疗效。方法回顾研究蝮蛇咬伤住院患者资料,根据中医治疗方案的不同,将符合纳入标准的病例分为对照组87例、试验组82例,对照组采用未优化中医方案,试验组采用优化中医方案,2组均配合以西医常规治疗,比较2组治疗前后伤肢肿胀疼痛程度、症状与体征积分、炎症指标、脏器功能指标、治愈率、治愈时间。结果在伤肢肿胀疼痛程度及症状消失时间、症状与体征积分方面,试验组治疗效果较对照组更为显著(P<0.05);2组治疗后6 d,WBC、N%、CRP、ALT、AST、Cr、NGAL、CK-MB指标均降低(P<0.05),试验组CRP、ALT、AST、Cr、NGAL指标较对照组降低更明显(P<0.05),但在降低CK-MB方面,2组效果相当,无明显差异(P>0.05);治愈率方面:试验组(97.56%,80/82)显著高于对照组(88.51%,77/87)(P<0.05),治愈时间方面:试验组较对照组用时更短(P<0.05)。结论中医优化方案能快速缓解蝮蛇咬伤肢体肿痛及全身症状、减轻机体炎症反应、改善重要脏器功能,临床效果好,值得推广应用。Objective To evaluate the clinical efficacy of the optimized traditional Chinese medicine treatment scheme for agkistrodon halys bite.Methods Review and study the data of hospitalized patients bitten by agkistrodon halys,according to the different treatment schemes of traditional Chinese medicine,the cases that meet the inclusion criteria are divided into the control group of 87 cases and the test group of 82 cases.The control group adopted the optimized traditional Chinese medicine treatment scheme,and the test group adopted the optimized traditional Chinese medicine treatment scheme,both groups cooperated with conventional western medicine treatment,and statistically compared the degree of swelling and pain of injured limbs,symptom and sign scores,inflammatory indicators,organ function indicators,cure rate and cure time.Results The treatment effect of the test group was more significant than that of the control group(P<0.05)in terms of the degree of swelling and pain of injured limbs,the time of symptom disappearance,and the score of symptoms and signs;on the 6th day after treatment,WBC、N%、CRP、ALT、AST、Cr、NGAL and CK-MB decreased in both groups(P<0.05),and CRP、ALT、AST、Cr、NGAL decreased more significantly in the test group than in the control group(P<0.05),however,in terms of reducing CK-MB,the effects of the two groups were similar,and there was no significant difference(P>0.05);the cure rate of the test group(97.56%,80/82)was significantly higher than that of the control group(88.51%,77/87)(P<0.05),and the cure time of the test group was significantly shorter than that of the control group(P<0.05).Conclusion The optimized Chinese medicine treatment plan for agkistrodon halys bite can quickly relieve the swelling and pain of the limbs and the systemic symptoms,reduce the inflammatory reaction of the body,and improve the function of important organs.It has good clinical effect and is worthy of clinical application.

关 键 词：蝮蛇咬伤 中医治疗方案 优化 肢体肿痛 炎症反应 脏器功能 疗效评价 

分 类 号：R269[医药卫生—中西医结合]