miR-155/GATA3/CD4^(+)T细胞通路对变应性鼻炎发病机制的调控  

miR-155/GATA3/CD4^(+)T cell pathway regulates pathogenesis of allergic rhinitis

作　　者：李荣荣 瞿申红[2] 张少杰[2] 黄雪颖 钟自玲 LI Rongrong;QU Shenhong;ZHANG Shaojie;HUANG Xueying;ZHONG Ziling(Youjiang Medical University for Nationalities,Baise 533000,China;Department of Otolaryngology,Head and Neck,the People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;Xingyuan Hospital of Yulin,Yulin 719000,China)

机构地区：[1]右江民族医学院,百色533000 [2]广西壮族自治区人民医院耳鼻咽喉头颈科,南宁530021 [3]榆林市星元医院,榆林719000

出　　处：《中国免疫学杂志》2024年第3期629-635,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金地区科学基金项目(81960186)。

摘　　要：变应性鼻炎(AR)指具有特异性体质的个体第二次接触相同致敏原后立即触发由免疫球蛋白E介导的Ⅰ型变态反应,其发病机制尚未明确,与多种基因、免疫细胞、细胞因子等密切相关。随着分子生物学和第二代基因测序技术快速发展,AR发病机制研究逐步深化、精准。研究发现miR-155和转录因子GATA3对AR发生发展有重要调控作用,进而影响CD4^(+)T淋巴细胞的优势分化趋势和ILC2增生。本文主要以miR-155/GATA3通路为中心,探讨相关上游基因和下游调控物质对AR发病机制的影响并进行综述。Allergic rhinitis(AR)is a typeⅠallergic reaction,which mediated by immunoglobulin E immediately when an individual with a special constitution is exposed to a same allergen for second time,whose pathogenesis has not been clarified yet,and closely related to genes,immune cells and cytokines.Pathogenesis of AR become more deeper and more accurate due to rapid develop-ment of molecular biology and second-generation gene sequencing technology.Current studies have found that miR-155 and transcrip-tion factor GATA3 have important regulatory effects on occurrence and development of AR,then affect dominant differentiation of CD4^(+)T lymphocytes and proliferation of ILC2.This article discusses and reviews pathogenesis of AR,which mainly focuses on miR-155/GATA3 pathway and effects of related upstream genes and downstream regulatory substances.

关 键 词：变应性鼻炎 MIR-155 GATA3 CD4^(+)T细胞 ILC2 

分 类 号：R246.81[医药卫生—针灸推拿学]