内质网应激的免疫抑制效应  

Endoplasmic reticulum stress induced immunosuppressive effects

作　　者：蒋丽娜[1] 蒋孙班 赵自刚[1] JIANG Lina;JIANG Sunban;ZHAO Zigang(Institute of Microcirculation,Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]河北北方学院微循环研究所,张家口075000

出　　处：《中国免疫学杂志》2024年第3期645-650,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(81670446)。

摘　　要：内质网应激(ERS)是内质网内环境失衡形成的一种亚细胞病理状态,是介导细胞凋亡的重要通路之一。研究发现各种免疫组织、细胞发生ERS后,产生免疫抑制效应,参与机体免疫稳态失调过程,影响多种疾病发生、转归与预后。本文综述免疫器官、免疫细胞中ERS的产生、信号调控及其在炎症性疾病和肿瘤等发展进程中的作用。Endoplasmic reticulum stress(ERS)is a subcellular pathological state formed by imbalance of environment in endoplasmic reticulum,and is regarded as an important pathway that mediates apoptosis.Recent studies have found that after ERS occurs in various immune tissues and cells,immunosuppressive effect that produced is involved in regulating body's immune homeo-stasis,affecting occurrence,outcome and prognosis of many diseases.This article reviews production of ERS,signal regulation and pathophysiological changes in immune organs and immune cells,and its role in development of inflammatory diseases and tumors.

关 键 词：内质网应激 免疫抑制 细胞凋亡 信号调控分子 免疫细胞 

分 类 号：R392.19[医药卫生—免疫学]