共刺激信号与心血管疾病的研究进展  

Research progress of costimulatory signals and cardiovascular diseases

作　　者：都昌乐 王瑜 梅仁彪 DU Changle;WANG Yu;MEI Renbiao(Department of Basic Medical Sciences,Medical College,Anhui University of Science&Technology,Huainan 232001,China)

机构地区：[1]安徽理工大学医学院基础医学系,淮南232001

出　　处：《中国免疫学杂志》2024年第3期656-662,共7页Chinese Journal of Immunology

基　　金：安徽高校省级自然科学重点研究项目(KJ2017A098,KJ2012A082);安徽理工大学博士科研基金(11046);安徽理工大学中青年学术骨干培养工程(10167)。

摘　　要：慢性炎症是心血管疾病发展的病理基础,以T细胞为主的免疫细胞可通过分泌促炎因子介导炎症反应影响心血管疾病进程。共刺激信号是T细胞活化的第二信号,通过磷脂酰肌醇3-激酶(PI3K)、丝裂原活化蛋白激酶(MAPK)、C-Jun氨基端激酶(JNK)等信号通路增强或抑制T细胞抗原受体(TCR)的信号传递,调控T细胞免疫功能、炎症因子的释放以及细胞外基质的生成,从而在心血管疾病中发挥重要作用。本文阐述了共刺激信号的传导机制以及与心血管疾病的相关性,以期为免疫治疗心血管疾病提供新的思路。Chronic inflammation is the pathological basis for the development of cardiovascular diseases.Immune cells domi-nated by T cells can secrete pro-inflammatory factors to mediate inflammation and affect the progress of cardiovascular diseases.The co-stimulatory signals is the second signal of T cell activation,which can enhance or inhibit the signal transmission of T cell antigen re-ceptor(TCR)by Phosphatidylinositol 3-kinase(PI3K),mitogen activated protein kinase(MAPK)and C-Jun N-terminal kinases(JNK),which play an important role in cardiovascular disease by regulating T cell immune function,the release of inflammatory cyto-kines,and the production of extracellular matrix.This article describes the transmission mechanism of costimulatory signals and their correlation with cardiovascular diseases,in order to provide new ideas for immunotherapy of cardiovascular diseases.

关 键 词：共刺激信号 心血管疾病 炎症 信号通路 

分 类 号：R392.3[医药卫生—免疫学]