MicroRNA调节免疫性血小板减少症CD4^(+)T细胞亚群免疫功能的研究进展  

Research progress of microRNA-mediated immune function of CD4^(+)T cells subsets in immune thrombocytopenia

作　　者：宋辉 郭一慧 许家威 曾清 程纬民[1,2] SONG Hui;GUO Yihui;XU Jiawei;ZENG Qing;CHENG Weimin(Graduate School,Guangxi University of Chinese Medicine,Nanning 530222,China;Department of Hematology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学研究生院,南宁530222 [2]广西中医药大学第一附属医院血液内科,南宁530023

出　　处：《中国免疫学杂志》2024年第3期663-667,共5页Chinese Journal of Immunology

基　　金：广西自然科学基金项目(2018GXNSFAA281082);广西中医药大学强基计划项目(XYJB074)。

摘　　要：MicroRNA(miRNA)是一种小分子非编码单链RNA,可广泛参与多种生物学过程,对调节机体的免疫功能具有重要作用。免疫性血小板减少症(ITP)是一种自身免疫性疾病,其发生和进展与miRNA介导CD4^(+)T细胞亚群的异常免疫调节密切相关。ITP患者miRNA的不同表达情况可影响CD4^(+)T细胞亚群的免疫功能,导致Th1/Th2、Th17/Treg的调节失衡和TFH的过度分化,引起细胞因子分泌异常。本文就ITP中miRNA介导的CD4^(+)T细胞亚群免疫功能失衡机制进行总结,以期为探索ITP的免疫机制和免疫治疗提供启发。MicroRNA(miRNA)is a kind of small non-coding single stranded RNA that can participate in multiple biological processes.It also plays an important role in regulating the immune function of the body.Immune thrombocytopenia(ITP)is an autoim-mune disease,whose cause and deterioration are closely related to miRNA regulates immune function of CD4^(+)T cells subsets.In ITP patients,different expression of miRNA can affect the immune function of CD4^(+)T cells subsets,which causes not only unbalanced ex-pression of Th1/Th2,Th17/Treg and excessive differentiation of TFH,but also abnormal cytokine secretion furthermore.This paper summarizes the unbalanced mechanism of miRNA regulating immune function of CD4^(+)T cells subsets in ITP,so as to provide inspira-tion for exploring the immunology and immunotherapy of ITP.

关 键 词：MICRORNA 免疫性血小板减少症 CD4^(+)T细胞亚群 

分 类 号：R558.2[医药卫生—血液循环系统疾病]