2,6-二氯-4-三氟甲基苯胺的连续流合成工艺  

Continuous-flow synthesis process of 2,6-dichloro-4-trifluoromethylaniline

作　　者：潘强彪 谢四维 应炜炜 李俊奇 PAN Qiangbiao;XIE Siwei;YING Weiwei;LI Junqi(Zhejiang Weihua New Materials Co.,Ltd.,Shaoxing 312300,Zhejiang,China)

机构地区：[1]浙江巍华新材料股份有限公司,浙江绍兴312300

出　　处：《世界农药》2024年第3期26-30,共5页World Pesticide

摘　　要：2,6-二氯-4-三氟甲基苯胺是一种可用于制备染料和农药等的重要中间体,尤其在农药领域应用广泛。以4-三氟甲基苯胺为起始原料,使用G1微通道反应器构建预热、氧氯化、降温工艺连续合成2,6-二氯-4-三氟甲基苯胺。考察了各工段温度、系统压力、物料流速和用量等工艺参数对反应的影响。优化条件下,反应收率可达83.0%,产品含量99.0%。该合成工艺利用微通道反应器良好的传质传热性能不仅保证了工艺体系安全,也提高了生产效率,为工业化技术的更新迭代提供了基础。2,6-Dichloro-4-trifluoromethylaniline is an important intermediate that can be used to prepare dyes and pesticides,especially in the field of pesticides.Starting from 4-trifluoromethylaniline,a G1 microchannel reactor was used to construct a preheating,oxychlorination,and cooling process for the continuous synthesis of 2,6-dichloro-4-trifluoromethylaniline.We investigated the effects of process parameters such as temperature,system pressure,material flow rate,and dosage on the reaction in each section.Under optimized conditions,the reaction yield can reach 83.0%and the product content is 99.0%.This synthesis process utilizes the excellent mass and heat transfer performance of microchannel reactors,which not only ensures the safety of the process system but also improves production efficiency,providing a foundation for the updating and iteration of industrial technology.

关 键 词：4-三氟甲基苯胺 2 6-二氯-4-三氟甲基苯胺 连续流 微通道反应器 

分 类 号：TQ450[化学工程—农药化工]