直肠原位凝胶的应用研究进展  

Research Progress in the Application of Rectal in Situ Gel

作　　者：雷晓萌 吴玉欢 彭颖 王灿坚 阳涛 李东勲[1,2] 张国松[1,2] 张文锍[1,2] LEI Xiaomeng;WU Yuhuan;PENG Ying;WANG Canjian;YANG Tao;LI Dongxun;ZHANG Guosong;ZHANG Wenliu(Jiangxi University of Chinese Medicine,Nanchang 330006,China;National Engineering Research Center of Chinese Medicine Solid Preparation Manufacturing Technology,Nanchang 330006,China)

机构地区：[1]江西中医药大学,南昌330006 [2]中药固体制剂制造技术国家工程研究中心,南昌330006

出　　处：《中国药学杂志》2024年第2期101-110,共10页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81960720);江西省主要学科学术和技术带头人资助项目(20182BCB22023);江西中医药大学校级科技创新团队发展计划;南昌市高层次科技创新人才“双百计划”项目资助;江西中医药大学博士科研启动基金项目资助(2021BSZR014);江西省大学生创新创业训练计划项目资助(S202210412091)。

摘　　要：直肠原位凝胶结合凝胶剂与直肠给药的双重特点,已成为目前研究的热点。直肠原位凝胶是一类以溶液状态给药后,能在用药部位立即发生相转变,由液态相转变为非化学交联半固体凝胶的制剂,具有独特的反向热凝胶性质、良好的缓释作用和生物利用度高等特点。笔者参考近10年来国内外相关文献,从直肠原位凝胶的特点、制备工艺、质量评价方法及应用等方面进行总结,通过分析直肠原位凝胶的研究进展,为研究和开发高效的直肠给药制剂提供新的思路。Rectal in situ gel combines the double characteristics of gel and rectal administration,and has become the focus of pharmaceutics research.Rectal in situ gel is a kind of non-chemical crosslinked semi-solid gel which can be transformed from liquid to gel immediately after administration in solution.It has unique reverse hot gel properties,good sustained release effect and high bioavailability.Referring to the relevant literature at domestic and abroad in the past 10 years,the characteristics,preparation technology,quality evaluation methods and application of rectal in situ gel were summarized.By analyzing the research progress of rectal in situ gel new ideas for the research and development of efficient rectal administration preparations are provided.

关 键 词：直肠给药 原位凝胶 制备工艺 质量评价 

分 类 号：R944[医药卫生—药剂学]