新型冠状病毒引起的病毒性角膜炎病例观察  

Case observation of viral keratitis caused by SARS-CoV-2

作　　者：谢孟针 张浩[1,2] 马可[1] 殷鸿波[1] 王力翔[1] 唐静 Xie Mengzhen;Zhang Hao;Ma Ke;Yin Hongbo;Wang Lixiang;Tang Jing(Department of Ophthalmology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;West China School of Medicine,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西医院眼科,四川省成都市610041 [2]四川大学华西临床医学院,四川省成都市610041

出　　处：《国际眼科杂志》2024年第4期495-499,共5页International Eye Science

基　　金：四川省科技计划项目(No.2021YFS0221);四川大学华西医院1.3.5临床孵化项目(No.2022HXFH032,2021-023,2022-014)。

摘　　要：目的:报告3例严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的病毒性角膜炎。方法:对3例新冠感染确诊患者行裂隙灯、眼压、角膜荧光染色、前段照相、活体共聚焦显微镜(IVCM)和常规眼底筛查。治疗包括更昔洛韦眼用凝胶、人工泪液和糖皮质激素滴眼液。结果:3例SARS-CoV-2角膜炎(SCK)患者经标准治疗后恢复良好。结论:SARS-CoV-2角膜炎通常表现为角膜上皮下浸润,可导致角膜上皮下神经纤维密度降低和树突状细胞(DC)增加。抗病毒治疗联合糖皮质激素已被证明是有效的。AIM:To report three cases of viral keratitis caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).METHODS:Slit lamp,intraocular pressure,corneal fluorescence staining,anterior segment photography,in vivo confocal microscopy(IVCM),and routine fundus screening were performed in the three confirmed patients.Treatment involved Ganciclovir,artificial tears and glucocorticoid eye drops.RESULTS:Three patients with SARS-CoV-2 keratitis(SCK)recovered well after standard treatment.CONCLUSION:SARS-CoV-2 keratitis typically presents as corneal subepithelial infiltration and can result in a decrease in corneal subepithelial nerve fiber density and an increase in dendritic cells(DC).Antiviral therapy in combination with glucocorticoid has proven to be effective.

关 键 词：角膜炎 COVID-19 SARS-CoV-2 更昔洛韦 

分 类 号：R511[医药卫生—内科学] R772.21[医药卫生—临床医学]