衰老性脱发  

Senescent Alopecia

作　　者：曹雨微 赵恒光 CAO Yuwei;ZHAO Hengguang(Department of Dermatology,the Second Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院皮肤科,重庆400010

出　　处：《中国皮肤性病学杂志》2024年第3期243-246,共4页The Chinese Journal of Dermatovenereology

基　　金：重庆市自然科学基金项目(cstc2021jcyj-msxmX0955)。

摘　　要：衰老性脱发常发生在50岁及以上人群,是一种毛囊的衰老表型,主要表现为一定年龄以后的毛干直径、毛发密度、毛囊生长期/休止期比率的逐年下降,并由此带来相应的生理和心理影响。但衰老性脱发的独立诊断仍存在争议,其发生的病理生理机制也不清楚,预防和减缓衰老性脱发的发生在当前还缺乏有效办法。本文旨在阐述当前有关衰老性脱发在定义、临床特征、与其他常见毛发疾病之间的关系、病理机制及预防治疗方法等方面的研究进展,以提高人们对该疾病的认知,并对未来的研究提供一些借鉴。Senescent alopecia is an aging phenotype of hair follicles,which is mainly manifested by a decrease in hair shaft diameter,density,and anagen/telogen ratio of hair follicles after a certain age,and thus brings corresponding physiological and psychological effects.However,the independence of senile alopecia is still controversial,and its pathophysiological mechanism is not clear.There is a lack of effective methods of preventing and slowing down the occurrence of senile alopecia.Here we aim to review the current research progress on senescent alopecia in terms of its definition,clinical features,relationship with other hair diseases,pathological mechanism,prevention and treatment,etc.,in order to improve the understanding of this disease and provide references for future research.

关 键 词：衰老性脱发 生理性脱发 毛囊干细胞 衰老 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]