瑞舒伐他汀联合康复训练治疗冠状动脉粥样硬化性心脏病合并高脂血症临床观察  

Clinical Observation of Rosuvastatin Combined with Rehabilitation Training in the Treatment of Coronary Heart Disease Complicated with Hyperlipidemia

作　　者：罗丹[1] 于亚群[1] 张林[1] 胥欣欣 程月英[1] LUO Dan;YU Yaqun;ZHANG Lin;XU Xinxin;CHENG Yueying(Chinese People's Liberation Army General Hospital,Beijing,China 100853)

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《中国药业》2024年第7期96-99,共4页China Pharmaceuticals

基　　金：北京市卫生健康委员会首都卫生发展科研专项项目[首发2020-1-1053]。

摘　　要：目的探讨瑞舒伐他汀联合康复训练治疗冠状动脉粥样硬化性心脏病(简称冠心病)合并高脂血症的临床疗效。方法选取医院2020年1月至2022年12月收治的冠心病合并高脂血症患者144例,按随机数字表法分为观察组和对照组,各72例。对照组患者予常规治疗和瑞舒伐他汀,观察组患者增加康复训练,两组均治疗12周。结果治疗后,两组患者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均明显低于治疗前,高密度脂蛋白胆固醇水平明显高于治疗前(P<0.05),且观察组均明显优于对照组(P<0.05);两组患者的左室射血分数、每分输出量(CO)水平均明显高于治疗前,血清心肌肌钙蛋白I明显低于治疗前(P<0.05),且观察组均明显优于对照组(P<0.05);两组患者的健康调查简表(SF-36)生理功能、生理职能、活力、社会功能、总体健康评分均明显高于治疗前(P<0.05),且观察组明显高于对照组(P<0.05)。结论瑞舒伐他汀联合康复训练可有效改善冠心病合并高脂血症患者的心功能,调节血脂水平,提高生活质量。Objective To investigate the clinical efficacy of rosuvastatin combined with rehabilitation training in the treatment of patients with coronary heart disease(CHD)complicated with hyperlipidemia.Methods A total of 144 patients with CHD complicated with hyperlipidemia admitted to the hospital from January 2020 to December 2022 were selected and divided into the control group and the observation group according to the random number table method,with 72 cases in each group.The patients in the control group received routine treatment and rosuvastatin,on this basis,the patients in the observation group received rehabilitation training.Both groups were treated for 12 weeks.Results After treatment,the levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)in the two groups were significantly lower than those before treatment,while level of high-density lipoprotein cholesterol(HDL-C)in the two groups was significantly higher than that before treatment(P<0.05),and those in the observation group were significantly better than those in the control group(P<0.05).The levels of left ventricular ejection fraction(LVEF)and cardiac output(CO)in the two groups were significantly higher than those before treatment,while the level of serum cardiac troponin I(cTnI)in the two groups was significantly lower than that before treatment(P<0.05),and those in the observation group were significantly better than those in the control group(P<0.05).The MOS item short form health survey(SF-36)scores(including physiological function,physiological function,vitality,social function,and overall healthh score)in the two groups was significantly higher than that before treatment(P<0.05),and that in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Rosuvastatin combined with rehabilitation training in the treatment of patients with CHD complicated with hyperlipidemia can effectively improve heart function,adjust blood lipid levels,and quality of life.

关 键 词：瑞舒伐他汀 康复训练 冠状动脉粥样硬化性心脏病 高脂血症 生活质量 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R972.6[医药卫生—药学]