1例氟康唑和沙利度胺致皮肌炎合并肺部感染的药学监护  

Pharmaceutical Care of a Patient with Dermatomyositis and Pulmonary Infection Caused by Fluconazole and Thalidomide

作　　者：刘培 穆海风 赵欣 LIU Pei;MU Haifeng;ZHAO Xin(The First Hospital of Baoding,Baoding,Hebei,China 071000)

机构地区：[1]河北省保定市第一医院,河北保定071000

出　　处：《中国药业》2024年第7期117-119,共3页China Pharmaceuticals

摘　　要：目的探讨临床药师在皮肌炎合并肺部感染治疗中的药学监护作用。方法临床药师参与1例皮肌炎合并肺部感染的药物治疗,分析患者出现药品不良反应的原因,并提供药学监护。结果患者出现四肢及口唇发麻后,临床药师建议停用可疑药品沙利度胺,医师采纳;患者四肢及口唇发麻未见明显改善,临床药师再次建议停用可疑药品氟康唑,患者四肢及口唇发麻症状改善。结论临床药师参与治疗方案的制订,提供药学服务,有助于提高患者的治疗效果,促进合理用药。同时,在药学查房过程中,密切监测使用沙利度胺的患者,一旦出现药源性周围神经炎,应立即减量或停用可疑药物。Objective To investigate the role of clinical pharmacists in pharmaceutical care in the treatment of patients with dermatomyositis and pulmonary infection.Methods A clinical pharmacist participated in the drug treatment of one case of dermatomyositis and pulmonary infection,analyzed the causes of adverse drug reactions in the patient,and provided pharmaceutical care.Results The clinical pharmacist suggested that the suspicious drug thalidomide should be stopped after the onset of numbness in limbs and lip numbness,which was adopted by the physician.However,the patients's numbness in limbs and lip did not improve significantly,and the clinical pharmacist once again suggested that the suspicious drug fluconazole should be stopped,and the patient's numbness in limbs and lip improved.Conclusion The participation of clinical pharmacists in the formulation of treatment plan and the provision of pharmaceutical care can help to improve the therapeutic effect and promote rational drug use.Meanwhile,it is suggested that patients who used thalidomide should be closely monitored during pharmaceutical ward rounds,and the suspected drugs should be reduced or stopped immediately after the occurrence of drug-induced peripheral neuritis.

关 键 词：皮肌炎 肺部感染 药学监护 氟康唑 利沙度胺 

分 类 号：R969.3[医药卫生—药理学] R971[医药卫生—药学]