巢式-碳硼烷硼氢键官能化反应研究进展  

Recent Progress in B—H Bond Functionalization of nido-Carboranes

作　　者：付雅彤 孙超凡 张丹 金成国[1] 陆居有 Fu Yatong;Sun Chaofan;Zhang Dan;Jin Chengguo;Lu Juyou(Materials and Chemical Engineering Department,Yibin University,Yibin,Sichuan 644000;School of Chemistry and Chemical Engineering,Hainan University,Haikou 570228)

机构地区：[1]宜宾学院材料与化学工程学部,四川宜宾644000 [2]海南大学化学化工学院,海口570228

出　　处：《有机化学》2024年第2期438-447,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.22161015);海南省自然科学基金(No.221RC448)资助项目.

摘　　要：巢式-碳硼烷是医学、材料科学和有机金属/配位化学等领域中多功能的重要砌块.近年来,巢式-碳硼烷的硼氢键直接活化及官能化反应受到了广泛关注.由于碳硼烷通常含有十个化学环境相似的硼氢键,因此区域选择控制一直是碳硼烷硼氢键活化的一个长期挑战.近年来,巢式-碳硼烷开口平面上的硼氢键官能化取得了重大进展,而非开口球面上的硼氢键选择性活化依然具有挑战性.总结了巢式-碳硼烷的区域选择性硼氢键官能化反应的研究进展,从开口面和非开口面硼氢键活化两个角度进行梳理.nido-Carboranes are versatile building blocks in medicine,materials science,and organometallic/coordination chemistry.Recently,direct B—H activation and functionalization of nido-carboranes have received much attention.Achieving regioselectivity in polyhedral cage B—H activation among ten chemically similar B—H vertices is a long-standing challenge in carborane chemistry.In this context,the activation of exo-cage B—H vertices on the open C2B3 pentagonal plane of nido-carboranes has been extensively studied.However,few direct activation reactions of B—H vertices that are located on the closed polyhedral sphere in nido-carborane have been reported.The recent progress on the regioselective B—H bond functionalization reaction of nido-carboranes is summarized.This topic is categorized into open plane exo-B—H activation and polyhedral sphere B—H activation.

关 键 词：碳硼烷 硼氢键活化 区域选择性 官能化 导向基团 

分 类 号：O621.251[理学—有机化学]