氮杂环卡宾催化实现的动力学拆分近期研究进展  

Kinetic Resolutions Enabled by N-Heterocyclic Carbene Catalysis:An Update

作　　者：杨爽 房新强 Yang Shuang;Fang Xinqiang(State Key Laboratory of Structural Chemistry,and Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Center for Excellence in Molecular Synthesis,Fujian Institute of Research on the Structure of Matter,University of Chinese Academy of Sciences,Fuzhou 350100)

机构地区：[1]中国科学院大学福建物质结构研究所,结构化学重点实验室煤制乙二醇重点实验室和分子合成卓越中心,福州350100

出　　处：《有机化学》2024年第2期448-480,共33页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071242,21871260);中国科学院战略重点研究方案(No.XDB20000000);福建省自然科学基金(No.2021J01522)资助项目.

摘　　要：动力学拆分是获得手性化合物的最常用方法之一.在过去的二十年里,氮杂环卡宾催化的动力学拆分得到了快速的发展,作者曾在2017年发表的综述文章中进行了一次总结.自此以后,该领域取得了一系列新的研究进展,将阐述这一研究领域自2017年年中至2023年的最新研究进展.Kinetic resolution is one of the most commonly used methods allowing access to enantioenriched compounds.The last two decades have seen the rapid development of kinetic resolutions enabled by N-heterocyclic carbene catalysis,and part of the achievements have been summarized in our previous review paper published in 2017.Since then,a series of new advances have been realized,and this review will provide an update of this field covering reports from mid-2017 to 2023.

关 键 词：动力学拆分 氮杂环卡宾 不对称催化 消旋体 对映体富集化合物 

分 类 号：O621.251[理学—有机化学]