α-氰醇甲磺酸酯在合成α-氨基腈类化合物中的应用  

Application ofα-Cyanohydrin Methanesulfonates for the Synthesis ofα-Aminonitriles

作　　者：张勇[1] 田志高[1] 黄琳[1] 侯秋飞[1] 范红红 汪万强[1] Zhang Yong;Tian Zhigao;Huang Lin;Hou Qiufei;Fan Honghong;Wang Wanqiang(School of Food Science and Technology&School of Chemical Engineering,Hubei University of Arts and Science,Xiangyang,Hubei 441053)

机构地区：[1]湖北文理学院食品科学技术学院•化学工程学院,湖北襄阳441053

出　　处：《有机化学》2024年第2期561-572,共12页Chinese Journal of Organic Chemistry

基　　金：湖北省自然科学基金(No.2021CFB160)资助项目.

摘　　要：报道了无过渡金属存在下α-氰醇甲磺酸酯与芳香胺的亲核取代反应.该方法的原料简单易得,反应条件温和,具有良好的底物适用性和官能团兼容性,以较好的产率得到了一系列重要的α-氨基腈类化合物.更重要的是,该方法还适用于含季碳中心的α-氰醇甲磺酸酯以及其它氮亲核试剂,得到的α-氨基腈非常容易衍生化.An efficient synthesis ofα-aminonitriles via nucleophilic substitution ofα-cyanohydrin methanesulfonates with aromatic amines was developed.This transition metal-free protocol has the advantages of cheap and easily available starting materials,broad substrate scope,excellent functional group compatibility,and very mild and simple operations.Furthermore,this strategy could also be applicable to quaternaryα-cyanohydrin methanesulfonates and various nitrogen nucleophiles.A range of derivatives were readily obtained through subsequent elaboration ofα-aminonitriles.

关 键 词：α-氨基腈 α-氰醇甲磺酸酯 芳香胺 亲核取代 

分 类 号：TQ226.6[化学工程—有机化工]