208例耐药结核病患者耐药特征分析  

Analysis of drug resistance characteristics in 208cases of drug-resistant tuberculosis

作　　者：马志强 陈薇 王晓燕 李才信 李晓琴 王霖 MA Zhiqiang;CHEN Wei;WANG Xiaoyan;LI Caixin;LI Xiaoqin;WANG Lin(The Third People’s Hospital of Kunming,Kunming 650301,China)

机构地区：[1]昆明市第三人民医院检验科,云南昆明650301

出　　处：《中国实验诊断学》2024年第3期304-306,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金项目(82260408);云南省教育厅科学研究基金项目(2022J0725);昆明市卫健委卫生科研课题项目(2022-11-01-011,2022-11-01-004);昆明市卫生科技人才培养“千”工程后备人选[2019-sw(后备)-25,2020-SW(后备)-60,2022-SW(后备)-70,2022-SW(后备)-85]。

摘　　要：目的为了解耐药结核病患者的耐药特征。方法收集2021年9月至2022年9月昆明市第三人民医院结核科收治的208例耐药结核病患者的实验室资料为研究对象,分析其在不同年龄、性别、标本类型、抗结核药物耐药中的占比情况。结果208例研究对象中。各年龄段耐药青少年5例(2.40%),青年97例(46.64%),中年70例(33.65%),老年36例(17.31%);不同性别中男性130例(62.50%),女性78例(37.50%)。各抗结核药物中单耐药97例(46.63%),多耐药22例(10.58%),耐多药89例(42.79%);单耐药中耐异烟肼最多,为51例(24.52%),其次为耐利福平24例(11.54%)。各标本耐药中痰液110例(52.89%),灌洗液83例(39.90%),脓液7例(3.37%),胸水3例(1.44%)、支刷物3例(1.44%)、脑脊液2例(0.96%)。结论耐药结核病患者以异烟肼为代表的单耐药为主,耐多药次之,不同人群中青年和男性耐药多见,各标本中痰液标本耐药占比最多。应注意耐药结核病患者检测及诊疗工作。Objective To understand the drug resistance characteristics of drug-resistant TB patients.Methods The laboratory data of 208drug-resistant TB patients admitted to the tuberculosis department of the Third People's Hospital of Kunming from September 2021to September 2022as study subjects,and analyzed their proportions in different ages,genders,specimen types,and anti-tuberculosis drug resistance.Results It was found that among 208study subjects.5 cases(2.40%)were adolescents,97cases(46.64%)were youths,70cases(33.65%)were middle-aged and 36cases(17.31%)were elderly among all ages of drug resistance;There were 130cases(62.50%)of males and 78cases(37.50%)of females by gender.97cases(46.63%)were mono-resistant,22cases(10.58%)were multi-resistant and 89cases(42.79%)were multidrug-resistant among various anti-tuberculosis drugs;among the monoresistant cases,51 cases(24.52%)were the most resistant to isoniazid,followed by 24cases(11.54%)rifampicin-resistant cases.Among the specimens resistant to each drug were sputum in 110cases(52.89%),lavage fluid in 83cases(39.90%),pus in 7 cases(3.37%),pleural fluid in 3cases(1.44%),branch brushings in 3cases(1.44%),and cerebrospinal fluid in 2cases(0.96%).Conclusion Patients with drug-resistant tuberculosis are dominated by isoniazid as the representative of single drug resistance,and multi-drug resistance is second,and drug resistance is more common among young people and men in different populations,and the detection in each specimen,Sputum specimens accounted for the largest proportion of drug resistance among all specimens,Attention should be paid to the detection and treatment of drug-resistant tuberculosis patients.

关 键 词：结核病 耐药特征 分析 

分 类 号：R52[医药卫生—内科学]