铁死亡及其在肝脏缺血-再灌注损伤中的研究进展  

Research progress of ferroptosis in liver ischemia-reperfusion injury

作　　者：李乐 朱志军[1] Li Le;Zhu Zhijun(Liver Transplantation Center,Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 100045,China;Department of Hepatobiliary Surgery,Chifeng Municipal Hospital,Chifeng,Inner Mongolia 024000,China)

机构地区：[1]首都医科大学附属北京友谊医院肝脏移植中心,100045 [2]内蒙古自治区赤峰市医院肝胆外科,024000

出　　处：《中华肝脏外科手术学电子杂志》2024年第1期109-113,共5页Chinese Journal of Hepatic Surgery(Electronic Edition)

摘　　要：铁死亡是近年来新发现的细胞死亡形式,研究认为机体主要通过铁死亡防御系统(System Xc-通路和MVA信号通路)和铁死亡执行系统(PUFA-PL代谢及过氧化和铁代谢)来动态调节铁死亡。越来越多研究认为铁死亡与不同器官缺血-再灌注损伤间存在相关性,其中巨噬细胞胞外诱捕网、Maresin结合组织再生物1、血红素氧合酶1修饰的骨髓间充质干细胞和HUWE-1等均通过影响铁死亡而影响肝脏缺血-再灌注损伤。因此本文对铁死亡与肝脏缺血-再灌注损伤间的相关研究进行综述报道,以期为肝脏器官保护提供理论基础和实践指导。Ferroptosis is a newly-discovered form of cell death in recent years.It is believed that the body can dynamically regulate ferroptosis mainly through ferroptosis defense system(System Xc-pathway and MVA signaling pathway)and ferroptosis executive system(PUFA-PL metabolism,peroxidation and iron metabolism).More and more studies have indicated that ferroptosis is correlated with ischemia-reperfusion injury of different organs.Among them,macrophage extracellular traps,Maresin-1,bone marrow mesenchymal stem cells modified by heme oxygenase 1 and HUWE-1 may all affect liver ischemia-reperfusion injury by affecting ferroptosis.Therefore,in this article,related studies between ferroptosis and liver ischemia-reperfusion injury were reviewed,aiming to provide theoretical basis and practical guidance for liver organ protection.

关 键 词：肝脏 缺血-再灌注损伤(IRI) 铁死亡 脂质过氧化物 活性氧(ROS) 

分 类 号：R657.3[医药卫生—外科学]